Multivoxel pattern analysis reveals dissociations between subjective fear and its physiological correlates.
Multivoxel pattern analysis reveals dissociations between subjective fear and its physiological correlates.
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DOI：
10.1038/s41380-019-0520-3
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发表时间：
2020-10
影响因子：
11
通讯作者：
Lau H
中科院分区：
文献类型：
--
作者：
Taschereau-Dumouchel V;Kawato M;Lau H
在焦虑和其他情感障碍的研究中，客观测量的生理反应通常被用作测量与病理相关的主观体验的代理。然而，这种普遍采用的“生物信号”方法最近受到了质疑，理由是主观经验和客观生理反应可能会分离。我们对功能性磁共振成像（fMRI）数据进行了基于机器学习的分析，以评估恐惧情况下的这个问题。虽然主观的恐惧和客观的生理反应相关的一般，各自的全脑多体素解码器的两个措施是不同的。一些关键的大脑区域，如杏仁核和杏仁核，似乎主要参与预测生理反应，而一些以前与元认知和意识感知有关的区域，包括前额叶皮层的一些区域，似乎主要预测恐惧的主观体验。目前的研究结果是在支持最近的呼吁谨慎假设一对一的映射之间的主观痛苦和他们假定的生物信号，尽管后者的客观和持续测量的生理方面的明显优势。
In studies of anxiety and other affective disorders, objectively measured physiological responses have commonly been used as a proxy for measuring subjective experiences associated with pathology. However, this commonly adopted “biosignal” approach has recently been called into question on the grounds that subjective experiences and objective physiological responses may dissociate. We performed machine-learning-based analyses on functional magnetic resonance imaging (fMRI) data to assess this issue in the case of fear. Although subjective fear and objective physiological responses were correlated in general, the respective whole-brain multivoxel decoders for the two measures were different. Some key brain regions such as the amygdala and insula appear to be primarily involved in the prediction of physiological reactivity, whereas some regions previously associated with metacognition and conscious perception, including some areas in the prefrontal cortex, appear to be primarily predictive of the subjective experience of fear. The present findings are in support of the recent call for caution in assuming a one-to-one mapping between subjective sufferings and their putative biosignals, despite the clear advantages in the latter’s being objectively and continuously measurable in physiological terms.
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