Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model.
Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model.
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红景天苷通过调节动脉粥样硬化模型中的细胞周期来减缓 EA.hy926 细胞衰老的进程
DOI：
10.3892/mmr.2017.7872
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发表时间：
2018-01
影响因子：
3.4
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Sun L;Dou F;Chen J;Chi H;Xing S;Liu T;Sun S;Chen C
衰老是心血管系统疾病的主要危险因素，如冠状动脉粥样硬化性心脏病，但对动脉粥样硬化（AS）与年龄相关的血管结构和功能下降之间的关系知之甚少。在此，我们结合组织学分析和分子生物学技术，证明内皮细胞中脂质沉积伴随着衰老和生长停滞。内皮细胞衰老足以导致AS;然而，我们发现红景天苷减少细胞内脂质沉积，减缓内皮细胞衰老的进程，抑制衰老相关分子的表达，并使视网膜母细胞瘤（Rb）蛋白磷酸化。进一步的研究证实红景天苷可增加氧化低密度脂蛋白（ox-LDL）处理的内皮细胞中S期细胞的百分比。总的来说，血管内皮细胞功能随着年龄和AS而下降，我们的数据表明红景天苷通过Rb磷酸化促进细胞周期从G 0/G1期到S期的进展来防止ox-LDL处理的内皮细胞衰老。我们第一次证明了AS和内皮细胞衰老之间复杂的相互作用，我们相信红景天苷是一种有前途的治疗衰老相关的AS。
Aging is the major risk factor for diseases of the cardiovascular system, such as coronary atherosclerotic heart disease, but little is known about the relationship between atherosclerosis (AS) and age-related declines in vascular structure and function. Here, we used histological analyses in combination with molecular biology techniques to show that lipid deposition in endothelial cell was accompanied by aging and growth arrest. Endothelial cell senescence is sufficient to cause AS; however, we found that salidroside reduced intracellular lipid deposition, slowed the progression of endothelial cell senescence and inhibited the expression of the senescence-related molecules and phosphorylated the retinoblastoma (Rb) protein. Further study confirmed that salidroside increased the percent of S phase cells in oxidized low-density lipoprotein (ox-LDL)-treated endothelial cells. Collectively, vascular endothelial cell function declined with age and AS, and our data suggested that salidroside prevented ox-LDL-treated endothelial cell senescence by promoting cell cycle progression from G0/G1 phase to S phase via Rb phosphorylation. We demonstrated for the first time the complex interactions between AS and endothelial cell senescence, and we believe that salidroside represents a promising therapy for senescence-related AS.
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影响因子：
3
作者：
Calcabrini, Cinzia;De Bellis, Roberta;Dacha, Marina
通讯作者：
Dacha, Marina
影响因子：
8.3
作者：
Hashimoto, Junichiro;Ito, Sadayoshi
通讯作者：
Ito, Sadayoshi
影响因子：
7.2
作者：
Pooja;Bawa, A. S.;Khanum, Farhath
通讯作者：
Khanum, Farhath
影响因子：
4.3
作者：
Martin, Nadine;Raguz, Selina;Gil, Jesus
通讯作者：
Gil, Jesus
DOI：
10.1080/10623320802487791
发表时间：
2008-01-01
影响因子：
--
作者：
Martin-Padura, Ines;de Nigris, Filomena;Napoli, Claudio
通讯作者：
Napoli, Claudio