The participation of cortical amygdala in innate, odour-driven behaviour.
The participation of cortical amygdala in innate, odour-driven behaviour.
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DOI：
10.1038/nature13897
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发表时间：
2014-11-13
期刊：
影响因子：
64.8
通讯作者：
Axel, Richard
中科院分区：
文献类型：
--
作者：
Root, Cory M.;Denny, Christine A.;Hen, Rene;Axel, Richard
先天行为在naïve动物没有事先学习或经验的情况下被观察到，这表明介导这些行为的神经回路是由基因决定的和定型的。将嗅觉信息从感觉器官传递到皮层和皮层下嗅觉中心的神经回路已经在解剖学上被定义，但负责对挥发性气味的先天反应的特定途径尚未被确定。我们已经设计了遗传策略，证明从嗅球到皮质杏仁核传递信息的刻板神经回路是先天厌恶和食欲行为所必需的。此外，我们还利用活动依赖基因的启动子arc来表达杏仁核皮层神经元中的光敏离子通道通道视紫红质，该通道被引发先天行为的气味激活。这些神经元的视觉激活导致了适当的行为，再现了对固有气味的反应。这些数据表明，皮质杏仁核在先天气味驱动行为的产生中起着关键作用，但并不排除皮质杏仁核参与习得性嗅觉行为。
Innate behaviors are observed in naïve animals without prior learning or experience, suggesting that the neural circuits that mediate these behaviors are genetically determined and stereotyped. The neural circuits that convey olfactory information from the sense organ to the cortical and subcortical olfactory centers have been anatomically defined but the specific pathways responsible for innate responses to volatile odors have not been identified. We have devised genetic strategies that demonstrate that a stereotyped neural circuit that transmits information from the olfactory bulb to cortical amygdala is necessary for innate aversive and appetitive behaviors. Moreover, we have employed the promoter of the activity-dependent gene, arc, to express the photosensitive ion channel, channelrhodopsin, in neurons of the cortical amygdala activated by odors that elicit innate behaviors. Optical activation of these neurons leads to appropriate behaviors that recapitulate the responses to innate odors. These data indicate that the cortical amygdala plays a critical role in the generation of innate odor-driven behaviors but do not preclude the participation of cortical amygdala in learned olfactory behaviors.
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