3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma
3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma
复制标题
3D打印可生物降解植入物作为骨肉瘤局部化疗的个体化给药系统
DOI：
10.1016/j.matdes.2019.108336
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发表时间：
2020-01
影响因子：
8.4
通讯作者：
Ping Liu
中科院分区：
文献类型：
--
作者：
Yonghui Wang;Liang Sun;Zhigang Mei;Fazhou Zhang;Meifang He;Cameron Fletcher;Fenglong Wang;Jingjing Yang;Dongbin Bi;Yanyan Jiang;Ping Liu
已经开发出一种3D打印技术，可以通过个性化的局部化疗治疗骨肉瘤。进行了一系列体内试验，这些试验密切模拟了真实的临床化疗条件。我们已经证明，3D打印的聚L-乳酸（PLLA）植入物是抗癌药物的特殊载体，可以设计成具有微调的物理形态和可控的微结构。其良好的生物降解性、体外细胞毒性、体外血液相容性、体内亚急性毒性和体内致敏试验证实了其生物相容性和药学特性。此外，我们已经证明，局部化疗与援助的准备PLLA植入物表现出抗骨肉瘤疗效上级传统化疗通过一系列的体内抗骨肉瘤试验，根据临床协议。所提出的3D打印药物递送系统可以同时实现骨肉瘤治疗中的个体化局部化疗、多药物递送、长期可持续药物释放和不再次手术。我们的研究使3D打印技术能够用于治疗骨肉瘤，并指导未来的临床试验。所建立的技术和原则也可适用于其他肿瘤的局部化疗。
A 3D printing technique has been developed which enables the treatment of osteosarcoma via personalized local chemotherapy. A series of in vivo trials were conducted which closely mimicked real clinical chemotherapeutic conditions. We have shown that 3D printed poly L-lactic acid (PLLA) implants are exceptional carriers for anticancer drugs and can be designed with finely tuned physical morphologies and controllable micropore structures. Their favorable biodegradability, in vitro cytotoxicity, in vitro blood compatibility, in vivo subacute toxicity, and in vivo sensitization tests have confirmed their biocompatibility and pharmaceutical properties. Furthermore, we have demonstrated that local chemotherapy with the assistance of the as-prepared PLLA implant exhibits an anti-osteosarcoma efficacy superior to traditional chemotherapy through a series of in vivo anti-osteosarcoma tests according to clinical protocols. The proposed 3D printed drug delivery system can simultaneously realize individual local chemotherapy, multi-drug delivery, long-term sustainable drug release, and non-reoperation in osteosarcoma treatment. Our studies enable the utilization of the 3D printing technique in the treatment of osteosarcomas and guide future clinical trials. The established techniques and principles can also be adapted to the local chemotherapy of other tumors.
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影响因子：
14.2
作者：
Klemm, K
通讯作者：
Klemm, K
影响因子：
4.6
作者：
Sodian, Ralf;Schmauss, Daniel;Schmitz, Christoph
通讯作者：
Schmitz, Christoph
影响因子：
8
作者：
Liu H;Slamovich EB;Webster TJ
通讯作者：
Webster TJ
影响因子：
11.2
作者：
C. Fournier;B. Hecquet;P. Bouffard;M. Vert;A. Caty;M. Vilain;L. Vanseymortier;S. Merle;A. Krikorian;J. Lefebvre
通讯作者：
C. Fournier;B. Hecquet;P. Bouffard;M. Vert;A. Caty;M. Vilain;L. Vanseymortier;S. Merle;A. Krikorian;J. Lefebvre
DOI：
10.3390/ma11020330
发表时间：
2018-02-24
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Qiang T;Wang J;Wolcott MP
通讯作者：
Wolcott MP