Less harmful acidic degradation of poly(lacticco-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition.
Less harmful acidic degradation of poly(lacticco-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition.
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DOI：
10.2147/nano.2006.1.4.541
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发表时间：
2006
影响因子：
8
通讯作者：
Webster TJ
中科院分区：
文献类型：
--
作者：
Liu H;Slamovich EB;Webster TJ
在过去的10年里，可生物降解的脂肪族聚酯，如聚(乳酸-乙醇酸)(PLGA)，由于其降解产物可以通过自然代谢途径去除，因此在骨组织工程中作为支架材料引起了越来越多的关注。然而，使用这些特定聚合物的一个主要问题是，它们的降解产物会降低局部的pH，进而引发炎症反应，损害种植部位的骨细胞健康。因此，本体外研究的目的是研究PLGA在加入分散的二氧化钛纳米颗粒后的降解行为。这项研究的结果首次证明，纳米二氧化钛在PLGA中的分散度增加，减少了PLGA降解所需的正常pH的有害变化。此外，先前的研究表明，二氧化钛纳米颗粒在PLGA中的分散度增加，显著改善了成骨细胞(骨形成细胞)的功能(如黏附、胶原合成、碱性磷酸酶活性和含钙矿物沉积)。通过这种方式，纳米二氧化钛-PLGA复合材料有望成为更有效的骨科组织工程应用的支架材料。
In the last 10 years, biodegradable aliphatic polyesters, such as poly(lactic-co-glycolic acid) (PLGA), have attracted increasing attention for their use as scaffold materials in bone tissue engineering because their degradation products can be removed by natural metabolic pathways. However, one main concern with the use of these specific polymers is that their degradation products reduce local pH, which in turn induces an inflammatory reaction and damages bone cell health at the implant site. Thus, the objective of the present in vitro study was to investigate the degradation behavior of PLGA when added with dispersed titania nanoparticles. The results of this study provided the first evidence that the increased dispersion of nanophase titania in PLGA decreased the harmful change in pH normal for PLGA degradation. Moreover, previous studies have demonstrated that the increased dispersion of titania nanoparticles into PLGA significantly improved osteoblast (bone-forming cell) functions (such as adhesion, collagen synthesis, alkaline phosphatase activity, and calcium-containing minerals deposition). In this manner, nanophase titania–PLGA composites may be promising scaffold materials for more effective orthopedic tissue engineering applications.
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影响因子：
3.5
作者：
Liu, HN;Slamovich, EB;Webster, TJ
通讯作者：
Webster, TJ
影响因子：
4.9
作者：
McManus, AJ;Doremus, RH;Bizios, R
通讯作者：
Bizios, R
影响因子：
3.7
作者：
Shih, C
通讯作者：
Shih, C
用于骨组织工程的多孔聚（α-羟基酸）/Bioglass®复合支架：I：：制备和体外表征
影响因子：
14
作者：
Maquet, V;Boccaccini, AR;Jérôme, R
通讯作者：
Jérôme, R