Release of endogenous cannabinoids from ventral tegmental area dopamine neurons and the modulation of synaptic processes.
Release of endogenous cannabinoids from ventral tegmental area dopamine neurons and the modulation of synaptic processes.
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DOI：
10.1016/j.pnpbp.2014.01.019
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发表时间：
2014-07-03
影响因子：
5.6
通讯作者：
Lupica, Carl R.
中科院分区：
文献类型：
--
作者：
Wang, Huikun;Lupica, Carl R.
内源性大麻素在哺乳动物脑的多种功能中发挥重要作用，包括调节奖赏相关的信息处理。实现这一目的的主要机制是突触传递的突触前调制。在奖励和奖励相关的行为中，前脑区域的多巴胺水平增加，最近已经证明这是由内源性大麻素系统调节的。因此，了解内源性大麻素如何被动员来调节冲击中脑多巴胺神经元的突触输入，对于完全理解这些分子在奖励行为、药物滥用和成瘾中所起的作用至关重要。在这里，我们总结了文献描述的短期和长期调节传入连接多巴胺神经元腹侧被盖区通过内源性大麻素激活大麻素CB1受体，并描述了这些分子通过奖励为基础的行为和暴露于滥用药物释放的机制。
Endogenous cannabinoids play important roles in a variety of functions in the mammalian brain, including the regulation reward-related information processing. The primary mechanism through which this achieved is the presynaptic modulation of synaptic transmission. During reward- and reinforcement-related behavior dopamine levels increase in forebrain areas and this has recently been shown to be modulated by the endocannabinoid system. Therefore, understanding how endocannabinoids are mobilized to modulate synaptic inputs impinging on midbrain dopamine neurons is crucial to a complete understanding of the roles that these molecules play in reward behavior, drug abuse and addiction. Here we summarize the literature describing short-term and long-term regulation of afferent connections on dopamine neurons in the ventral tegmental area via endocannabinoid activation of cannabinoid CB1 receptors, and describe the mechanisms through which these molecules are released during reward-based behavior and exposure to abused drugs.
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
成瘾和大脑奖励和反发达途径。
影响因子：
--
作者：
Gardner EL
通讯作者：
Gardner EL
DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
25
作者：
Carlson, G;Wang, Y;Alger, BE
通讯作者：
Alger, BE
影响因子：
4.7
作者：
Kortleven, Christian;Bruneau, Laura Charlotte;Trudeau, Louis-Eric
通讯作者：
Trudeau, Louis-Eric