Cardiac Shockwave Therapy - A Novel Therapy for Ischemic Cardiomyopathy?

Cardiac Shockwave Therapy - A Novel Therapy for Ischemic Cardiomyopathy?
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DOI:
10.3389/fcvm.2022.875965
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发表时间:
2022
影响因子:
3.6
通讯作者:
--
中科院分区:
医学3区
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--
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在过去的几十年里,冲击波疗法(SWT)作为再生医学应用的一种治疗方法获得了越来越多的兴趣,例如骨折和伤口的愈合。最近,临床前研究已经阐明了SWT在心肌缺血中再生作用的潜在机制。SWT的机械刺激可能通过释放生长因子、调节炎症反应和血管生成来诱导缺血组织的再生作用。SWT对先天免疫系统的激活和嘌呤能受体的刺激似乎可以增强受损组织的血管化和再生,并改善其功能。有趣的是,小型单中心研究表明,SWT可能改善缺血性心脏病患者的心绞痛、运动耐量和血流动力学。因此,SWT可能是一种很有前途的技术,可以诱导缺血性心脏病患者的心脏保护或修复。
Over the past decades, shockwave therapy (SWT) has gained increasing interest as a therapeutic approach for regenerative medicine applications, such as healing of bone fractures and wounds. More recently, pre-clinical studies have elucidated potential mechanisms for the regenerative effects of SWT in myocardial ischemia. The mechanical stimulus of SWT may induce regenerative effects in ischemic tissue via growth factor release, modulation of inflammatory response, and angiogenesis. Activation of the innate immune system and stimulation of purinergic receptors by SWT appears to enhance vascularization and regeneration of injured tissue with functional improvement. Intriguingly, small single center studies suggest that SWT may improve angina, exercise tolerance, and hemodynamics in patients with ischemic heart disease. Thus, SWT may represent a promising technology to induce cardiac protection or repair in patients with ischemic heart disease.
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