Mosquito immune defenses against Plasmodium infection.

Mosquito immune defenses against Plasmodium infection.
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DOI:
10.1016/j.dci.2009.12.005
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发表时间:
2010-04
影响因子:
2.9
通讯作者:
Dimopoulos, George
Dimopoulos, George
中科院分区:
生物学3区
文献类型:
--
作者:
Cirimotich, Chris M.;Dong, Yuemei;Garver, Lindsey S.;Sim, Shuzhen;Dimopoulos, George

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疟疾的病原体疟原虫必须经历复杂的发育转变,并在蚊子先天免疫系统的攻击下存活下来,才能通过载体从一个宿主传播到另一个宿主。在这里,我们讨论了最近的发现蚊子的先天免疫信号通路的作用,在预防感染疟原虫寄生虫,识别和新的抗寄生虫分子的机制描述,自然细菌窝藏在蚊子中肠的作用可能发挥这种免疫防御,和介导中肠感染的重要寄生虫和载体分子。
The causative agent of malaria, Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. Here we discuss recent findings on the role of the mosquito's innate immune signaling pathways in preventing infection by the Plasmodium parasite, the identification and mechanistic description of novel anti-parasite molecules, the role that natural bacteria harbored in the mosquito midgut might play in this immune defense, and the crucial parasite and vector molecules that mediate midgut infection.
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