The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds.
The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds.
复制标题
非编码RNA用于糖尿病伤口的进展、前景和挑战。
DOI：
10.1016/j.omtn.2021.03.015
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发表时间：
2021-06-04
期刊：
影响因子：
--
通讯作者：
Deng C
中科院分区：
文献类型：
--
作者：
Li J;Wei M;Liu X;Xiao S;Cai Y;Li F;Tian J;Qi F;Xu G;Deng C
慢性糖尿病性伤口影响患者的生活质量，对个人和卫生保健系统造成重大的社会和经济负担。虽然已经探索了慢性糖尿病伤口的治疗方法，但仍然缺乏有效的治疗策略；因此，必须探索替代策略。近年来，非编码RNA在糖尿病创面中的异常表达受到了广泛关注，因为它是糖尿病创面发生发展的重要因素。本文综述了三种常见的非编码RNA （microRNA [miRNA]、长链非编码RNA [lncRNA]和环状RNA [circRNA]）在糖尿病创面中的调控作用，并讨论了非编码RNA在糖尿病创面中的诊断、治疗潜力和挑战。本文从遗传和分子水平对糖尿病创面诊断和治疗的新策略进行了探讨。本文系统综述了非编码RNA对糖尿病创面愈合的调控作用。选题新颖，内容丰富，逻辑清晰。这将有助于非编码RNA治疗糖尿病创面，为非编码RNA的临床应用提供理论依据。
Chronic diabetic wounds affect the quality of life of patients, resulting in significant social and economic burdens on both individuals and the health care system. Although treatment methods for chronic diabetic wounds have been explored, there remains a lack of effective treatment strategies; therefore, alternative strategies must be explored. Recently, the abnormal expression of non-coding RNA in diabetic wounds has received widespread attention since it is an important factor in the development of diabetic wounds. This article reviews the regulatory role of three common non-coding RNAs (microRNA [miRNA], long non-coding RNA [lncRNA], and circular RNA [circRNA]) in diabetic wounds and discusses the diagnosis, treatment potential, and challenges of non-coding RNA in diabetic wounds. This article provides insights into new strategies for diabetic wound diagnosis and treatment at the genetic and molecular levels. This manuscript systematically reviews the regulatory effects of non-coding RNA on diabetic wound healing. The topic is novel, rich in content, and clear in logic. It will be helpful for non-coding RNA treatment of diabetic wounds and provides a theoretical basis for clinical application of the non-coding RNA.
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DOI：
10.1161/atvbaha.117.310663
发表时间：
2018-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Das S;Reddy MA;Senapati P;Stapleton K;Lanting L;Wang M;Amaram V;Ganguly R;Zhang L;Devaraj S;Schones DE;Natarajan R
通讯作者：
Natarajan R
影响因子：
5.2
作者：
Everett E;Mathioudakis N
通讯作者：
Mathioudakis N
影响因子：
17.1
作者：
Eming SA;Martin P;Tomic-Canic M
通讯作者：
Tomic-Canic M
影响因子：
2.9
作者：
Gallant-Behm, Corrie L.;Piper, Joseph;Jackson, Aimee L.
通讯作者：
Jackson, Aimee L.
影响因子：
2.9
作者：
Caskey, Robert C.;Zgheib, Carlos;Liechty, Kenneth W.
通讯作者：
Liechty, Kenneth W.