Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy.
Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy.
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DOI：
10.1002/cncr.24177
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发表时间：
2009-04-15
期刊：
影响因子：
6.2
通讯作者：
Gillenwater AM
中科院分区：
文献类型：
--
作者：
Schwarz RA;Gao W;Redden Weber C;Kurachi C;Lee JJ;El-Naggar AK;Richards-Kortum R;Gillenwater AM
光谱学是一种非侵入性的技术，在口腔发育不良和早期癌症的诊断中具有潜在的应用价值。在这项研究中，我们评估了深度敏感光谱（DSOS）系统的诊断性能，以区分非肿瘤性口腔粘膜异型增生和癌。招募口腔病变患者和无任何口腔异常的志愿者参与研究。使用DSOS系统测量选定的口腔部位的自体荧光和漫反射光谱。对124名受试者的424个口腔部位进行了测量和分析，其中60名口腔病变患者的154个部位和64名正常志愿者的270个部位。测量的光谱用于开发基于计算机的算法，以识别发育异常或癌症的存在。使用患者部位的组织病理学和正常志愿者部位的临床印象的金标准计算灵敏度和特异性。在以下方面观察到口腔光谱的差异：（1）肿瘤部位与非肿瘤部位，（2）角化组织与非角化组织，以及（3）口腔组织内的浅深度与深深度。基于来自310个非角质化解剖部位（颊、舌、口底和唇）的光谱的算法在训练集中产生了0.96的受试者工作特征（ROC）曲线下面积，在验证集中产生了0.93的受试者工作特征（ROC）曲线下面积。选择性靶向上皮和浅基质深度区域的能力似乎在诊断上有用。对于非角化的口腔部位，这种客观诊断技术的灵敏度和特异性与专家观察员的临床诊断相当。因此，DSOS有可能在社区环境中增加口腔癌筛查工作。
Optical spectroscopy is a noninvasive technique with potential applications for diagnosis of oral dysplasia and early cancer. In this study we evaluated the diagnostic performance of a depth-sensitive optical spectroscopy (DSOS) system for distinguishing dysplasia and carcinoma from non-neoplastic oral mucosa. Patients with oral lesions and volunteers without any oral abnormalities were recruited to participate. Autofluorescence and diffuse reflectance spectra of selected oral sites were measured using the DSOS system. 424 oral sites in 124 subjects were measured and analyzed, including 154 sites in 60 patients with oral lesions and 270 sites in 64 normal volunteers. Measured optical spectra were used to develop computer-based algorithms to identify the presence of dysplasia or cancer. Sensitivity and specificity were calculated using a gold standard of histopathology for patient sites and clinical impression for normal volunteer sites. Differences in oral spectra were observed in: (1) neoplastic vs. non-neoplastic sites, (2) keratinized vs. non-keratinized tissue, and (3) shallow vs. deep depths within oral tissue. Algorithms based on spectra from 310 non-keratinized anatomic sites (buccal, tongue, floor of mouth, and lip) yielded an area under the receiver operating characteristic (ROC) curve of 0.96 in the training set and 0.93 in the validation set. The ability to selectively target epithelial and shallow stromal depth regions appears diagnostically useful. For non-keratinized oral sites the sensitivity and specificity of this objective diagnostic technique are comparable to that of clinical diagnosis by expert observers. Thus DSOS has potential to augment oral cancer screening efforts in community settings.
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影响因子：
3.4
作者：
Badizadegan, K;Backman, V;Feld, MS
通讯作者：
Feld, MS
影响因子：
4.7
作者：
Gillenwater, Ann;Papadimitrakopoulou, Vali;Richards-Kortum, Rebecca
通讯作者：
Richards-Kortum, Rebecca
DOI：
10.1016/j.jphotobiol.2006.05.004
发表时间：
2006-11-01
影响因子：
5.4
作者：
Majumder, S. K.;Gupta, A.;Gupta, P. K.
通讯作者：
Gupta, P. K.
影响因子：
3.3
作者：
Fischer, DJ;Epstein, JB;Schwartz, SM
通讯作者：
Schwartz, SM
影响因子：
4.8
作者：
Poate, TWJ;Buchanan, JAG;Porter, SR
通讯作者：
Porter, SR