Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study.
Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study.
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DOI：
10.1007/s00592-012-0440-z
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发表时间：
2013-06
影响因子：
3.8
通讯作者：
Bowden, Donald W.
中科院分区：
文献类型：
--
作者：
Cox, Amanda. J.;Lehtinen, Allison B.;Xu, Jianzhao;Langefeld, Carl D.;Freedman, Barry I.;Carr, J. Jeffrey;Bowden, Donald W.
硒蛋白S（SelS）以前与一系列炎症标志物相关，特别是在心血管疾病（CVD）的背景下。本研究的目的是研究SELS基因变异在2型糖尿病（T2 DM）患者亚临床CVD风险和死亡率中的作用。在1220名来自家庭糖尿病心脏研究的欧洲美国人中，研究了标记SELS的10种多态性与冠状动脉（CAC）、颈动脉（CarCP）和腹主动脉钙化斑块（AACP）、颈动脉内膜中层厚度（IMT）和其他已知CVD危险因素之间的关联。SELS SNP关联的最强证据是CarCP; rs 28665122（5′区; β=0.329，p=0.044），rs 4965814（内含子5; β=0.329，p=0.036）、rs 28628459（3′区; β=0.331，p=0.039）和rs7178239（下游; β=0.375，p=0.016）均相关。此外，rs 12917258（内含子5）与CAC相关（β =-0.230，p=0.032），rs 4965814、rs 28628459和rs 9806366均与自我报告的既往CVD病史相关（p=0.020-0.043）。这些结果表明，在该富含T2 DM的样本中，SELS区域在亚临床CVD的发展中具有潜在作用。进一步了解这些关系的机制可能对预测和管理T2 DM的CVD并发症很重要。
Selenoprotein S (SelS), has previously been associated with a range of inflammatory markers, particularly in the context of cardiovascular disease (CVD). The aim of this study was to examine the role of SELS genetic variants in risk for subclinical CVD and mortality in individuals with type 2 diabetes mellitus (T2DM). The association between 10 polymorphisms tagging SELS and coronary (CAC), carotid (CarCP) and abdominal-aortic calcified plaque (AACP), carotid intima media thickness (IMT) and other known CVD risk factors was examined in 1220 European Americans from the family-based Diabetes Heart Study. The strongest evidence of association for SELS SNPs was observed for CarCP; rs28665122 (5′ region; β=0.329, p=0.044), rs4965814 (intron 5; β=0.329, p=0.036), rs28628459 (3′ region; β=0.331, p=0.039) and rs7178239 (downstream; β=0.375, p=0.016) were all associated. In addition, rs12917258 (intron 5) was associated with CAC (β =−0.230, p=0.032) and rs4965814, rs28628459 and rs9806366 were all associated with self reported history of prior CVD (p=0.020–0.043). These results suggest a potential role for the SELS region in the development subclinical CVD in this sample enriched for T2DM. Further understanding the mechanisms underpinning these relationships may prove important in predicting and managing CVD complications in T2DM.
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影响因子：
5
作者：
Carr, JJ;Crouse, JR;Burke, GL
通讯作者：
Burke, GL
DOI：
10.1073/pnas.021506298
发表时间：
2001-01-16
影响因子：
11.1
作者：
Buetow, KH;Edmonson, M;Braun, A
通讯作者：
Braun, A
影响因子：
5.1
作者：
Hyrenbach, S.;Pezzini, A.;Grond-Ginsbach, C.
通讯作者：
Grond-Ginsbach, C.
影响因子：
3.8
作者：
Miyamoto, Michiaki;Kotani, Kazuhiko;Taniguchi, Nobuyuki
通讯作者：
Taniguchi, Nobuyuki
影响因子：
8.3
作者：
Lange, LA;Bowden, DW;Freedman, BI
通讯作者：
Freedman, BI