Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a.
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a.
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Wnt-1 和 Wnt-3a 对神经轴背侧命运的调节。
DOI：
10.1073/pnas.94.25.13713
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发表时间：
1997
影响因子：
11.1
通讯作者：
I. Dawid
中科院分区：
文献类型：
--
作者：
J. Saint;Xi He;Xi He;H. Varmus;I. Dawid
Members of the Wnt family of signaling molecules are expressed differentially along the dorsal-ventral axis of the developing neural tube. Thus we asked whether Wnt factors are involved in patterning of the nervous system along this axis. We show that Wnt-1 and Wnt-3a, both of which are expressed in the dorsal portion of the neural tube, could synergize with the neural inducers noggin and chordin in Xenopus animal explants to generate the most dorsal neural structure, the neural crest, as determined by the expression of Krox-20, AP-2, and slug. Overexpression of Wnt-1 or Wnt-3a in the neuroectoderm of whole embryos led to a dramatic increase of slug and Krox-20-expressing cells, but the hindbrain expression of Krox-20 remained unaffected. Enlargement in the neural crest population could occur even when cell proliferation was inhibited. Wnt-5A and Wnt-8, neither of which is expressed in the dorsal neuroectoderm, failed to induce neural crest markers. Overexpression of glycogen synthase kinase 3, known to antagonize Wnt signaling, blocked the neural-crest-inducing activity of Wnt-3a in animal explants and inhibited neural crest formation in whole embryos. We suggest that Wnt-1 and Wnt-3a have a role in patterning the neural tube along its dorsoventral axis and function in the differentiation of the neural crest.
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影响因子：
10.5
作者：
CHRISTIAN, JL;MOON, RT
通讯作者：
MOON, RT
影响因子：
4.6
作者：
J. Christian;J. McMahon;A. McMahon;R. Moon
通讯作者：
J. Christian;J. McMahon;A. McMahon;R. Moon
影响因子：
4.5
作者：
Dass RA;Sarshad AA;Carson BB;Feenstra JM;Kaur A;Obrdlik A;Parks MM;Prakash V;Love DK;Pietras K;Serra R;Blanchard SC;Percipalle P;Brown AM;Vincent CT
通讯作者：
Vincent CT
Xwnt-8b：母系表达的爪蟾 Wnt 基因，在建立背腹轴方面具有潜在作用。
DOI：
10.1242/dev.121.7.2177
发表时间：
1995
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Cui,Y;Brown,JD;Moon,RT;Christian,JL
通讯作者：
Christian,JL
Xwnt-3A 和 Xwnt-1 在非洲爪蟾胚胎神经组织中的重叠表达。
影响因子：
2.7
作者：
Wolda,SL;Moody,CJ;Moon,RT
通讯作者：
Moon,RT