Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results.
Anxious Depression and Neurocognition among Middle-Aged and Older Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Results.
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DOI：
10.1016/j.jagp.2017.06.002
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
González HM
中科院分区：
文献类型：
--
作者：
Camacho A;Tarraf W;Jimenez DE;Gallo LC;Gonzalez P;Kaplan RC;Lamar M;Khambaty T;Thyagarajan B;Perreira KM;Hernandez R;Cai J;Daviglus ML;Wassertheil-Smoller S;González HM
本研究的目的是研究语言学习，流畅性和处理速度与焦虑抑郁症之间的关联不同的西班牙裔/拉丁美洲人。我们假设一个负相关的焦虑抑郁症与神经认知之间的西班牙裔/拉丁美洲人的不同遗产。数据来自西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）。样本包括9，311名年龄在45-74岁（平均：56.6）的参与者。抑郁症流行病学研究中心（CESD-10项目）和Spielberger状态-特质焦虑量表的项目的潜在类别分析被用来推导出一个焦虑抑郁结构。神经认知测量包括简短西班牙语英语语言学习测试（B-SEVLT学习和回忆试验）、单词流畅性（WF）、数字符号替代（DSS）测试和整体认知评分（GCS）的评分。我们拟合调查线性回归模型来检验焦虑抑郁症与认知功能之间的关系。在男性中，71%报告低，24%中度，5%高ADS。在女性中，54.7%报告低ADS，33.2%中度ADS，12.2%高ADS。在控制年龄、性别、体重、社会人口学特征、心血管危险因素和抗抑郁药使用后，我们发现中度和高度焦虑抑郁（参考：低）与B-SEVLT学习和回忆、DSST和GCS之间存在显著负相关（p值≤0.05）。中度但不高的焦虑抑郁与WF呈负相关（p值<0.05）。西班牙裔/拉丁裔人群中焦虑-抑郁障碍的增加与神经认知功能下降相关。需要进行纵向研究来确定暂时性并推断负面情绪症状是否先于认知缺陷。
The purpose of this study is to examine the association between verbal learning, fluency, and processing speed with anxious-depression symptomatology among diverse Hispanic/Latinos. We hypothesize an inverse association of anxious-depression with neurocognition among Hispanic/Latinos of different heritage. Data are from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The sample included 9,311participants aged 45–74 years (Mean:56.6). A latent class analysis of items from the Center for Epidemiological Studies for Depression (CESD-10 item) and the Spielberger State-Trait Anxiety Inventory was used to derive an anxious-depression construct. Neurocognitive measures included scores on the Brief Spanish English Verbal Learning Test (B-SEVLT learning and recall trials), Word Fluency (WF), Digit Symbol Substitution (DSS) test and a Global Cognitive Score (GCS). We fit survey linear regression models to test the associations between anxious-depression symptomatology and cognitive function. Among men, 71% reported low, 24% moderate, and 5% high ADS. Among women, 54.7% reported low, 33.2% moderate, and 12.2% high ADS. After controlling for age, sex, weight, socio-demographic characteristics, cardiovascular risk factors, and antidepressant use, we found significant inverse associations between moderate and high anxious-depression (ref:low) with B-SEVLT learning and recall, DSST and GCS (p-values≤0.05). Moderate, but not high, anxious-depression was inversely associated with WF (p-value<0.05). Increased anxious-depression symptomatology is associated with decreased neurocognitive function among Hispanic/Latinos. Longitudinal studies are needed to establish temporality and infer if negative emotional symptoms precede cognitive deficits.
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影响因子：
3.3
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Ionescu DF;Niciu MJ;Henter ID;Zarate CA
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