Serum transferrin receptor in children with respiratory infections
Serum transferrin receptor in children with respiratory infections
复制标题
呼吸道感染患儿血清转铁蛋白受体
DOI：
10.1038/sj.ejcn.1601496
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发表时间：
2003
影响因子：
4.7
通讯作者：
B. Sesikeran
中科院分区：
文献类型：
--
作者：
P. Bhaskaram;K. M. Nair;Nagalla Balakrishna;P. Ravinder;B. Sesikeran
目的：为了研究感染对铁状态的儿童患有急性，轻度或重度呼吸道感染的影响，并确定贫血感染的性质，使用血清转铁蛋白受体（sTfR）levels.Design：43名儿童年龄在3和5岁之间 ，没有感染的证据，并接受铁补充剂在过去的100天作为对照。21例轻度上呼吸道感染患儿和94例急性肺炎住院患儿为实验组。血红蛋白（Hb），sTfR和血清铁蛋白估计在所有的儿童在诊断时，并再次在感染后的第15和第30天，在那些谁是follow-up.Results：平均值（95%CI）sTfR为6.08（5.1-7.1）mg/L的健康非贫血儿童。上呼吸道感染对Hb和sTfR没有影响，但显著升高血清铁蛋白水平。83%的肺炎患儿在诊断时Hb低于110 g/l，sTfR平均升高18.0（15.7-20.3）mg/l。 在感染的第15天，平均sTfR下降至14.3（11.3-17.4）mg/l，在30天进一步上升至22.9（13.0-31.9）mg/l。血清铁蛋白在诊断时显著升高（85.9; 71.1-100.8 µg/l），在第15天（89.1; 68-110.1 µg/l），30天下降。结论：严重下呼吸道感染通过阻断铁从储存池中释放而加重缺铁性红细胞生成。 sTfR可能不是评估暴露于严重感染的儿童的真实铁状况的敏感和特异的工具。赞助：由印度政府科学和技术部提供资金（DST编号SP/SO/B-29/96），印度新德里。
Objective: To study the effect of infection on iron status in children suffering from acute, mild or severe respiratory infections and to determine the nature of anemia in infection using serum transferrin receptor (sTfR) levels.Design: Forty-three children aged between 3 and 5 y with no evidence of infection and receiving iron supplements in the preceding 100 days served as controls. Twenty-one children with mild upper respiratory infection and 94 children hospitalized for acute pneumonia constituted the experimental group. Hemoglobin (Hb), sTfR and serum ferritin were estimated in all the children at the time of diagnosis and again on the 15th and 30th days after the infection in those who were available for follow-up.Results: Mean (95% CI) sTfR was 6.08 (5.1–7.1) mg/l in healthy non-anemic children. Upper respiratory infection had no impact on Hb or sTfR but it significantly elevated serum ferritin levels. Eighty-three percent of the children with pneumonia had Hb less than 110 g/l at the time of diagnosis and had elevated mean sTfR, 18.0 (15.7–20.3) mg/l. There was a decline in mean sTfR by the 15th day of infection to 14.3 (11.3–17.4) mg/l with further rise to 22.9 (13.0–31.9) mg/l by 30 days. Serum ferritin was significantly elevated at the time of diagnosis (85.9; 71.1–100.8 µg/l) as well as at 15 days (89.1; 68–110.1 µg/l) with a decline by 30 days.Conclusion: Severe lower respiratory infection exaggerates iron-deficient erythropoiesis by blocking release of iron from the storage pools. sTfR may not be a sensitive and specific tool of assessing true iron status of children exposed to severe infections.Sponsorship: Funding from the Department of Science and Technology (DST no. SP/SO/B-29/96), Government of India, New Delhi, India.
影响因子：
7.1
作者：
AHLUWALIA, N;LAMMIKEEFE, CJ;HALEY, NR
通讯作者：
HALEY, NR
影响因子：
8
作者：
Rettmer, RL;Carlson, TH;Labbé, RF
通讯作者：
Labbé, RF