Cell intrinsic characteristics of human cord blood naïve CD4T cells.
Cell intrinsic characteristics of human cord blood naïve CD4T cells.
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DOI：
10.1016/j.imlet.2017.11.011
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发表时间：
2018-01
影响因子：
4.4
通讯作者：
Iwashima M
中科院分区：
文献类型：
--
作者：
Jacks RD;Keller TJ;Nelson A;Nishimura MI;White P;Iwashima M
It has been generally considered that the perinatal immune system is less inflammatory compared to the adult system and type 2 responses predominate perinatal immune responses against antigens. Indeed, previous studies in mice showed that there are cell-intrinsic differences between neonatal and adult CD4 T cells. However, studies on human cord blood and infant blood demonstrated that human perinatal T cells do not produce elevated levels of Th2 cytokines with the exception of IL-13. These data raise the question if human T cells in the perinatal blood fundamentally differ from adult T cells. To decipher differences between human perinatal and adult T cells, we performed a focused comparative analysis on purified naïve CD4 T cells from umbilical cord blood (UCB) and adult peripheral blood. Our data demonstrate naïve CD4 T cells from UCB differ from adult naïve CD4 T cells in surface expression of CD26, dipeptidyl peptidase-4. While only a fraction of effector/memory T cells from adult blood express CD26, practically all T cells from UCB express high levels of CD26. We also determined that Th1/Th2 polarizing conditions induce UCB CD4 T cells to produce higher levels of IFN-γ and IL -5 compared to adult CD4 T cells, respectively. These data demonstrate intrinsic differences between UCB and adult naive CD4 T cells and suggest that human perinatal immune responses involve more complex mechanisms than the previously thought Th2-dominant responses.
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影响因子：
15.3
作者：
Kimmig, Sonja;Przybylski, Grzegorz K;Schmidt, Christian A;Laurisch, Katja;Mowes, Beate;Radbruch, Andreas;Thiel, Andreas
通讯作者：
Thiel, Andreas
影响因子：
4.4
作者：
Bengsch, Bertram;Seigel, Bianca;Thimme, Robert
通讯作者：
Thimme, Robert
影响因子：
4.6
作者：
Amlot, PL;Tahami, F;Rawlings, E
通讯作者：
Rawlings, E
影响因子：
4.8
作者：
Webster, Robin B.;Rodriguez, Yelitza;Vercelli, Donata
通讯作者：
Vercelli, Donata
DOI：
10.1111/aji.12083
发表时间：
2013-04
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Burt TD
通讯作者：
Burt TD