The role of autophagy in metal-induced urogenital carcinogenesis.
The role of autophagy in metal-induced urogenital carcinogenesis.
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DOI：
10.1016/j.semcancer.2021.03.022
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发表时间：
2021-11
影响因子：
14.5
通讯作者：
Damodaran C
中科院分区：
文献类型：
--
作者：
Saran U;Tyagi A;Chandrasekaran B;Ankem MK;Damodaran C
环境和/或职业暴露于砷（As）、镉（Cd）和铬（Cr）等金属已被证明可诱导各种器官（包括泌尿生殖系统）的致癌作用。然而，负责金属诱导的致癌机制仍然难以捉摸。我们和其他人已经表明，金属是自噬的有效诱导剂，这被认为是一种适应性应激反应，允许暴露于金属的细胞在恶劣的环境中生存。虽然很少，最近的实验研究表明，砷和镉通过自噬促进肿瘤的发生和抑制自噬信号抑制金属诱导的致癌作用。鉴于新出现的作用，自噬参与金属诱导的致癌作用，本审查明确的机制作用的自噬和潜在的信号通路参与作为，镉，铬诱导的泌尿生殖系统致癌。
Environmental and/or occupational exposure to metals such as Arsenic (As), Cadmium (Cd), and Chromium (Cr) have been shown to induce carcinogenesis in various organs, including the urogenital system. However, the mechanisms responsible for metal-induced carcinogenesis remain elusive. We and others have shown that metals are potent inducers of autophagy, which has been suggested to be an adaptive stress response to allow metal-exposed cells to survive in hostile environments. Albeit few, recent experimental studies have shown that As and Cd promote tumorigenesis via autophagy and that inhibition of autophagic signaling suppressed metal-induced carcinogenesis. In light of the newly emerging role of autophagic involvement in metal-induced carcinogenesis, the present review focuses explicitly on the mechanistic role of autophagy and potential signaling pathways involved in As-, Cd-, and Cr-induced urogenital carcinogenesis.
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