Emerging view of the human virome.

Emerging view of the human virome.
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DOI:
10.1016/j.trsl.2012.03.006
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发表时间:
2012-10
期刊:
Translational research : the journal of laboratory and clinical medicine
影响因子:
--
通讯作者:
Storch GA
Storch GA
中科院分区:
其他
文献类型:
--
作者:
Wylie KM;Weinstock GM;Storch GA

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人类病毒体是在人类体内或人体上发现的所有病毒的集合,包括真核和原核病毒。真核病毒显然对人类健康有重要影响,从轻微的、自限性的急性或慢性感染到严重或致命的后果。原核生物病毒还可以通过影响细菌群落结构和功能来影响人类健康。因此,对病毒的定义是了解微生物如何影响人类健康和疾病的重要一步。我们回顾了病毒分析方面的进展,这是由高通量、深度测序技术的进步推动的。这些研究的亮点包括病毒与临床表型的关联以及可能是重要病原体的新病毒的描述。总而言之,这些研究表明,对人类病毒体的分析至关重要,因为我们的目标是了解微生物群落如何影响人类健康和疾病。对人类病毒体的描述将刺激未来的工作,以了解病毒体如何影响人类的长期健康、免疫力和对合并感染的反应。对病毒体的分析最终可能会影响各种临床症状患者的治疗。
The human virome is the collection of all viruses that are found in or on humans, including both eukaryotic and prokaryotic viruses. Eukaryotic viruses clearly have important effects on human health, ranging from mild, self-limited acute or chronic infections to those with serious or fatal consequences. Prokaryotic viruses can also influence human health by affecting bacterial community structure and function. Therefore, definition of the virome is an important step toward understanding how microbes affect human health and disease. We review progress in virome analysis, which has been driven by advances in high-throughput, deep sequencing technology. Highlights from these studies include the association of viruses with clinical phenotypes and description of novel viruses that may be important pathogens. Together these studies indicate that analysis of the human virome is critical as we aim to understand how microbial communities influence human health and disease. Descriptions of the human virome will stimulate future work to understand how the virome affects long-term human health, immunity, and response to coinfections. Analysis of the virome ultimately may affect the treatment of patients with a variety of clinical syndromes.
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