Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design.
Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design.
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促甲状腺激素独立于甲状腺激素，可提高冠心病患者的血清总胆固醇水平：横断面设计
DOI：
10.1186/1743-7075-9-44
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发表时间：
2012-05-23
影响因子：
4.5
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Xu C;Yang X;Liu W;Yuan H;Yu C;Gao L;Zhao J
背景 TSH 和血脂之间的关系是矛盾的，因为很少有研究排除甲状腺激素 (TH) 的潜在影响。本研究的目的是评估血清TSH水平与血脂之间的独立于TH的关系。方法对1302例经冠状动脉造影确诊的CHD患者进行回顾性研究。首先分析甲状腺功能障碍的患病率和分布。为了评估 TSH 对血脂的影响，在调整经典因素和 TH 后进行 Pearson 相关分析。为了计算TSH对血清胆固醇水平的影响程度，采用偏最小二乘法和附加统计方法。结果排除后，共纳入568例患者（男270例，女298例，平均年龄63.56±11.376岁）。患者甲状腺功能障碍患病率为18.66%，其中甲减患病率（15.32%）高于甲亢患病率（3.34%）。即使在调整了性别、年龄、吸烟状况、空腹血糖水平和 TH 等混杂因素后，TSH 对血清总胆固醇 (TC) 水平也有显着的积极影响 (r = 0.095，p= 0.036)。 TSH水平每升高1 mIU/L，血清TC值可能升高0.015580712 mmol/L。结论TSH可以独立于TH而升高CHD患者的TC水平。本研究表明 TSH 的潜在生理作用以及在 CHD 患者中维持适当 TSH 水平的重要性。
BackgroundThe relationship between TSH and the lipid profile is contradictory because few studies have excluded the potential influence of the thyroid hormones (TH). The aim of the present study was to evaluate the relationship between serum TSH levels and the lipid profile independent of TH.Methods1302 CHD patients diagnosed by coronary angiography were retrospectively studied. The prevalence and distribution of thyroid dysfunction were analyzed first. To assess the impact of TSH on serum lipids, Pearson’s correlation analysis was performed after adjustments for classic factors and TH. To calculate the extent of the effect of TSH on the serum cholesterol level, the partial least squares method and additional statistical methods were used.ResultsAfter the exclusions, a total of 568 patients (270 males and 298 females with a mean age of 63.56 ± 11.376 years) were selected. The prevalence of thyroid dysfunction among the patients was 18.66%, and the prevalence of hypothyroidism (15.32%) was higher than that of hyperthyroidism (3.34%). Even after adjusting for confounding factors, such as sex, age, smoking status, fasting plasma glucose levels and TH, a significant positive impact of TSH on the serum total cholesterol (TC) level was revealed (r = 0.095,p= 0.036). Each 1 mIU/L increase in the TSH level might be linked to a 0.015580712 mmol/L elevation of the serum TC value.ConclusionsTSH can increase the TC level in CHD patients independent of TH. The present study suggests a potential physiological role of TSH and the importance of maintaining an appropriate TSH level in CHD patients.
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影响因子：
120.7
作者：
Cappola, AR;Fried, LP;Ladenson, PW
通讯作者：
Ladenson, PW
影响因子：
2.7
作者：
Coceani, Michele;Iervasi, Giorgio;L'Abbate, Antonio
通讯作者：
L'Abbate, Antonio
影响因子：
3.1
作者：
Williams, G. R.
通讯作者：
Williams, G. R.
影响因子：
13.5
作者：
Tian, Limin;Song, Yongfeng;Zhao, Jiajun
通讯作者：
Zhao, Jiajun
影响因子：
11.1
作者：
Iqbal, A.;Jorde, R.;Figenschau, Y.
通讯作者：
Figenschau, Y.