Biomedical Imaging in Experimental Models of Cardiovascular Disease.

Biomedical Imaging in Experimental Models of Cardiovascular Disease.
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心血管疾病实验模型中的生物医学成像。

DOI:
10.1161/circresaha.122.320306
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发表时间:
2022-06-10
影响因子:
20.1
通讯作者:
Scherrer-Crosbie, Marielle
Scherrer-Crosbie, Marielle
中科院分区:
医学1区
文献类型:
--
作者:
Sosnovik, David E.;Scherrer-Crosbie, Marielle

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在过去的二十年中,生物医学成像取得了重大进展,现在可以在心血管疾病的小动物模型中对许多生理,细胞和分子过程进行非侵入性成像。这些技术中的许多也可以用于人类,提供病理生理学背景并帮助定义模型的临床相关性。超声仍然是最广泛使用的方法,专用高频系统可以在小鼠中获得非常详细的图像。同样,已经开发了专用的小动物断层扫描系统,用于小鼠的磁共振(MR)、正电子发射断层扫描(PET)、荧光成像和计算机断层扫描。在这篇文章中,我们回顾了超声和PET在小动物模型中的应用,以及磁共振中新兴的对比机制,如扩散张量成像,超极化MR,化学交换饱和转移成像,MR弹性成像和应变,动脉自旋标记和分子成像。
Major advances in biomedical imaging have occurred over the last two decades and now allow many physiological, cellular and molecular processes to be imaged non-invasively in small animal models of cardiovascular disease. Many of these techniques can be also used in humans, providing pathophysiological context and helping to define the clinical relevance of the model. Ultrasound remains the most widely used approach and dedicated high frequency systems can obtain extremely detailed images in mice. Likewise, dedicated small animal tomographic systems have been developed for magnetic resonance (MR), positron-emission tomography (PET), fluorescence imaging and computed tomography in mice. In this article we review the use of ultrasound and PET in small animal models as well as emerging contrast mechanisms in magnetic resonance such as diffusion tensor imaging, hyperpolarized MR, chemical exchange saturation transfer imaging, MR-elastography and strain, arterial spin labeling and molecular imaging.
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