Relationship between Anaemia, Haemolysis, Inflammation and Haem Oxygenase-1 at Admission with Sepsis: a pilot study.
Relationship between Anaemia, Haemolysis, Inflammation and Haem Oxygenase-1 at Admission with Sepsis: a pilot study.
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DOI：
10.1038/s41598-018-29558-5
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发表时间：
2018-07-25
影响因子：
4.6
通讯作者：
Mooney JP
中科院分区：
文献类型：
--
作者：
Ekregbesi P;Shankar-Hari M;Bottomley C;Riley EM;Mooney JP
由于溶血和/或炎症，血红素加氧酶-1（HO-1）的上调可导致免疫功能受损。贫血在脓毒症患者中很常见，但脓毒症相关贫血的后果知之甚少。在这里，我们的目的是确定早期入院后贫血、溶血、炎症和HO-1诱导的患病率和程度。我们假设炎症或感染诱导的溶血导致败血症相关性贫血，这将导致HO-1的表达。在这项研究中，通过ELISA和微珠阵列分析了70名因败血症入院重症监护12小时内的成年患者的血浆中的贫血、溶血和炎症标志物。大多数（82.6%）患者贫血，有溶血迹象（血红素、触珠蛋白、血红素结合蛋白和HO-1浓度升高）。有趣的是，血红蛋白和IL-10的浓度与HO-1浓度呈中度正相关（Hb：r = 0.32，p = 0.007; IL-10 r = 0.39，p = 0.0008），而HO-1浓度与血红素结合蛋白呈弱负相关（r =-0.23，p = 0.055）。贫血虽然常见，但与HO-1浓度无关。调整混杂因素后，HO-1诱导似乎主要与IL-10浓度相关，而不是溶血。诊断时疾病严重程度与早期血浆IL-10（r = 0.35，p = 0.003）和HO-1（r = 0.24，p = 0.048）浓度相关。值得注意的是，血红素、HO-1和IL-10的入院水平是生存的指标。
Upregulation of haem oxygenase-1 (HO-1), due to haemolysis and/or inflammation, can lead to impaired immune function. Anaemia is common among sepsis patients, but the consequences of sepsis-associated anaemia are poorly understood. Here, our objective was to determine the prevalence and extent of anaemia, haemolysis, inflammation, and HO-1 induction after early hospital admission. We hypothesised that inflammation- or infection-induced haemolysis contributes to sepsis-associated anaemia and that this will lead to expression of HO-1. In this study, plasma obtained from seventy adult patients within 12 hours of admission to intensive care due to sepsis were analysed for anaemia, haemolysis and inflammatory markers by ELISA and microbead array. The majority (82.6%) of patients were anaemic with evidence of haemolysis (raised haem, haptoglobin, haemopexin, and HO-1 concentrations). Interestingly, concentrations of both haemoglobin and IL-10 were moderately positively correlated with HO-1 concentration (Hb: r = 0.32, p = 0.007; IL-10 r = 0.39, p = 0.0008) whereas HO-1 concentration was weakly negatively correlated with haemopexin (r = −0.23, p = 0.055). Anaemia, while common, was not associated with HO-1 concentration. After adjusting for confounding, HO-1 induction appears to be associated primarily with IL-10 concentration rather than haemolysis. Disease severity at diagnosis was correlated with early plasma IL-10 (r = 0.35, p = 0.003) and HO-1 (r = 0.24, p = 0.048) concentrations. Notably, admission levels of haem, HO-1, and IL-10 were indicators of survival.
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影响因子：
--
作者：
Knauert M;Vangala S;Haslip M;Lee PJ
通讯作者：
Lee PJ
影响因子：
6.7
作者：
Lokken KL;Mooney JP;Butler BP;Xavier MN;Chau JY;Schaltenberg N;Begum RH;Müller W;Luckhart S;Tsolis RM
通讯作者：
Tsolis RM
恶性疟疾和非洲儿童败血症中迁移抑制因子和诱导型一氧化氮合酶的组织分布。
影响因子：
3
作者：
Clark, IA;Awburn, MM;Whitten, RO;Harper, CG;Liomba, NG;Molyneux, ME;Taylor, TE
通讯作者：
Taylor, TE
DOI：
10.1038/nri3552
发表时间：
2013-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Jung, Jae Yun;Kwak, Young Ho;Suh, Gil Joon
通讯作者：
Suh, Gil Joon