Potential role of radial glia in adult neurogenesis of teleost fish
Potential role of radial glia in adult neurogenesis of teleost fish
复制标题
放射状胶质细胞在硬骨鱼成年神经发生中的潜在作用
作者：
G. Zupanc;S. Clint
放射状胶质细胞在成体中枢神经系统内的持续存在是鱼类中普遍存在的现象。基于对硬骨鱼Apteronotus eptorhynchus的一系列研究，我们认为这种持续性的一个功能是放射状胶质细胞参与了成体神经发生，即成体中枢神经系统新神经元的产生和进一步发育。特别是，已有证据表明，放射状胶质细胞参与了完整脑和再生脑中迁移的年轻神经元的指导；可能作为新神经元产生的前体细胞；以及它作为促进新神经元生成、分化和/或存活的营养物质的来源。这些功能不仅有助于完整的大脑不断产生新的神经元，也有助于损伤的大脑用新生成的细胞取代受损的细胞，而且它们还提供了行为可塑性的细胞底物的重要组成部分。Glia 43：77-86,2003。©2003 Wiley-Liss公司
Persistence of radial glia within the adult central nervous system is a widespread phenomenon among fish. Based on a series of studies in the teleost species Apteronotus leptorhynchus, we propose that one function of this persistence is the involvement of radial glia in adult neurogenesis, i.e., the generation and further development of new neurons in the adult central nervous system. In particular, evidence has been obtained for the involvement of radial glia in the guidance of migrating young neurons in both the intact and the regenerating brain; for a possible role as precursor cells from which new neurons arise; and for its role as a source of trophic substances promoting the generation, differentiation, and/or survival of new neurons. These functions contribute not only to the potential of the intact brain to generate new neurons continuously, and of the injured brain to replace damaged cells by newly generated ones, but they also provide an essential part of the cellular substrate of behavioral plasticity. GLIA 43:77–86, 2003. © 2003 Wiley‐Liss, Inc.
DOI：
10.1073/pnas.95.6.3168
发表时间：
1998-03-17
影响因子：
11.1
作者：
Gould, E;Tanapat, P;Fuchs, E
通讯作者：
Fuchs, E
弱电刀鱼（Eigenmannia sp.）成年期间中央后核/前起搏核神经元的出生和迁移。
DOI：
10.1073/pnas.89.20.9539
发表时间：
1992
影响因子：
11.1
作者：
Zupanc,GK;Zupanc,MM
通讯作者：
Zupanc,MM