DCC protein as a predictor of distant metastases after curative surgery for rectal cancer
DCC protein as a predictor of distant metastases after curative surgery for rectal cancer
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DCC蛋白作为直肠癌根治性手术后远处转移的预测因子
DOI：
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发表时间：
1998
影响因子：
3.9
通讯作者：
F. Köckerling
中科院分区：
文献类型：
--
作者：
M. Reymond;O. Dworak;Stephan Remke;W. Hohenberger;T. Kirchner;F. Köckerling
目得：本研究的目的是确定DCC（大肠癌缺失）蛋白预测直肠癌根治性手术后异时远处转移的价值。DCC蛋白基因位于染色体18q上，最近有报道称其在结直肠癌中具有预后价值。这一发现可能对国际抗癌联合会II期直肠癌的治疗有意义，尽管进行了最佳手术，但仍有14%的患者发生远处转移。方法：来自85例直肠癌根治性手术后发生远处转移但无局部复发的患者的石蜡包埋组织与来自保持无病患者的85个样本相匹配。匹配标准是肿瘤分期、年龄、性别和手术日期。免疫组化法检测DCC蛋白的表达。随访终点为疾病复发和死亡。平均随访9.6年。没有患者接受局部或全身辅助治疗。结果：DCC蛋白在64.9%的肿瘤组织中有表达。DCC蛋白的不表达对生存率有负面影响（P=0.03）。对于所有肿瘤分期，检测随后发生远处转移的敏感性为42%，特异性为71%。在II期癌症中，阳性预测值为19%，阴性预测值为88%。结论：我们的研究结果证实，DCC蛋白是直肠癌患者的一个有用的预后标志物，但DCC蛋白发生异时转移的阳性预测值似乎不足以证明辅助治疗措施在II期直肠癌。
PURPOSE: The aim of this study was to determine the value of DCC (deleted in colorectal cancer) protein for predicting metachronous distant metastases after curative surgery for rectal cancer. The DCC protein—for which a gene has been located on chromosome 18q—has recently been reported to have a prognostic value in colorectal cancer. This finding might have implications for treatment of International Union Against Cancer Stage II rectal carcinoma, in which distant metastases will develop in 14 percent of patients despite optimal surgery. METHODS: Paraffin-embedded tissues from 85 patients who developed distant metastases, but no local recurrence, after curative surgery for rectal cancer were matched with 85 samples from patients who remained disease-free. Matching criteria were tumor stage, age, gender, and date of surgery. Expression of DCC protein was assessed using immunohistochemistry. End points of follow-up were recurrence of disease and death. Mean follow-up was 9.6 years. No patient received either local or systemic adjuvant therapy. RESULTS: The DCC protein was found to be expressed in 64.9 percent of tumor samples. Nonexpression of DCC protein had an negative influence on survival (P=0.03). For all tumor stages together, sensitivity of the test for subsequent occurrence of distant metastases was 42 percent and specificity was 71 percent. In Stage II cancers, the positive predictive value was 19 percent, and the negative predictive value was 88 percent. CONCLUSIONS: Our results confirm that DCC protein is a useful prognostic marker in patients with rectal carcinomas, but the positive predictive value of DCC protein for occurrence of metachronous metastases does not appear to be sufficient to justify adjuvant therapeutic measures in Stage II rectal cancer.
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影响因子：
158.5
作者：
JEN, J;KIM, HG;HAMILTON, SR
通讯作者：
HAMILTON, SR
DCC 基因抑制转化的人上皮细胞的恶性表型。
DOI：
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发表时间：
1995
期刊：
Oncogene.
影响因子：
--
作者：
Klingelhutz,AJ;Hedrick,L;Cho,KR;McDougall,JK
通讯作者：
McDougall,JK
DOI：
10.1073/pnas.89.21.10065
发表时间：
1992-11-01
影响因子：
11.1
作者：
PEINADO, MA;MALKHOSYAN, S;PERUCHO, M
通讯作者：
PERUCHO, M
影响因子：
56.9
作者：
FEARON, ER;CHO, KR;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
158.5
作者：
Shibata, D;Reale, MA;Summerhayes, IC
通讯作者：
Summerhayes, IC