Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage
Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage
复制标题
受智能蘑菇启发的可压印和轻度可拆卸 (MILD) 微针模式，用于有效的 COVID-19 疫苗接种和分散式信息存储
DOI：
10.1021/acsnano.1c10718
复制
发表时间：
2022-04
期刊：
影响因子：
17.1
通讯作者：
Xiaoyuan Chen
中科院分区：
文献类型：
--
作者：
Qilin Li;Rengui Xu;Huiling Fan;Jiarong Xu;Yunruo Xu;Peng Cao;Yan Zhang;Tao Liang;Yang Zhang;Wei Chen;Zheng Wang;Lin Wang;Xiaoyuan Chen
控制 2019 年冠状病毒病 (COVID-19) 传播和降低死亡率的关键高度依赖于普通人群安全有效地使用疫苗。目前的COVID-19疫苗接种实践（肌肉注射溶液疫苗）受到严重依赖医疗专业人员、依从性差、疫苗接种记录程序繁琐等限制，导致卫生资源浪费和疫苗接种覆盖率低等。在这项研究中，我们开发了一种受蘑菇启发的智能可印迹和轻可拆卸（MILD）微针平台，用于有效、便捷地注射多剂量COVID-19 疫苗和分散的疫苗信息存储。蘑菇状结构使 MILD 系统可以轻松压入皮肤并从贴片底座上分离，充当“纹身”，无需任何存储设备即可在原位记录疫苗计数，提供快速访问和轻松读出，为患者和卫生专业人员节省大量宝贵的时间和精力。加载灭活的 SARS-CoV-2 病毒疫苗后，MILD 系统在体内诱导高水平的针对 SARS-CoV-2 受体结合域（RBD）的抗体，而不会引起全身毒性和局部损伤。总的来说，这个智能交付平台通过其疫苗交付和原位数据存储的双重功能，成为提高 COVID-19 疫苗接种效果的有前景的载体，从而在帮助遏制 COVID-19 大流行或死灰复燃方面展现出巨大的潜力。
The key to controlling the spread of the coronavirus disease 2019 (COVID-19) and reducing mortality is highly dependent on the safe and effective use of vaccines for the general population. Current COVID-19 vaccination practices (intramuscular injection of solution-based vaccines) are limited by heavy reliance on medical professionals, poor compliance, and laborious vaccination recording procedures, resulting in a waste of health resources and low vaccination coverage, etc. In this study, we developed a smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle platform for the effective and convenient delivery of multidose COVID-19 vaccines and decentralized vaccine information storage. The mushroom-like structure allows the MILD system to be easily pressed into the skin and detached from the patch base, acting as a “tattoo” to record the vaccine counts in situ without any storage equipment, offering quick accessibility and effortless readout, saving a great deal of valuable time and energy for both patients and health professionals. After loading inactivated SARS-CoV-2 virus-based vaccines, MILD system induced a high level of antibodies against the SARS-CoV-2 receptor-binding domain (RBD) in vivo without eliciting systemic toxicity and local damage. Collectively, this smart delivery platform serves as a promising carrier to improve COVID-19 vaccination efficacy through its dual capabilities of vaccine delivery and in situ data storage, thus exhibiting great potential for helping to contain the COVID-19 pandemic or a resurgence.
登录
查看更多内容
非病毒Covid-19疫苗输送系统。
影响因子：
16.1
作者：
Park KS;Sun X;Aikins ME;Moon JJ
通讯作者：
Moon JJ
影响因子：
1.2
作者：
Machado, Rogerio Bonassi;Monteiro, Ilza Maria Urbano;Magalhães, Jarbas;Guazzelli, Cristina Aparecida Falbo;Brito, Milena Bastos;Finotti, Marta Franco;Lubianca, Jaqueline Neves;Sakamoto, Luis Carlos;Franceschini, Silvio Antonio
通讯作者：
Franceschini, Silvio Antonio
DOI：
10.1016/j.jconrel.2019.11.022
发表时间：
2019-11
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
D. S. Uppu;M. Turvey;Abdul Rahim Mohamed Sharif;Katell Bidet;Yanpu He;V. Ho;Anagha Tambe;J. Lescar;E. Tan;K. Fink;Jianzhu Chen;P. Hammond
通讯作者：
D. S. Uppu;M. Turvey;Abdul Rahim Mohamed Sharif;Katell Bidet;Yanpu He;V. Ho;Anagha Tambe;J. Lescar;E. Tan;K. Fink;Jianzhu Chen;P. Hammond
影响因子：
7.2
作者：
Baker, Courtney C.;Creinin, Mitchell D.
通讯作者：
Creinin, Mitchell D.
影响因子：
13.6
作者：
Li, Wei;Tang, Jie;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.