Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats.
Chronic antidepressant treatment rescues abnormally reduced REM sleep theta power in socially defeated rats.
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DOI：
10.1038/s41598-021-96094-0
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发表时间：
2021-08-18
影响因子：
4.6
通讯作者：
Tatebayashi Y
中科院分区：
文献类型：
--
作者：
Matsuda Y;Ozawa N;Shinozaki T;Aoki K;Nihonmatsu-Kikuchi N;Shinba T;Tatebayashi Y
慢性抗抑郁药（AD）治疗对啮齿动物慢性应激模型睡眠障碍的影响尚未得到彻底研究。在这里，我们表明，大鼠的慢性社会失败压力（SDS）诱导长期的社会回避，睡眠结构的改变（增加总快速眼动（REM）睡眠持续时间，回合，缩短REM潜伏期），和上下文，但没有线索的恐惧记忆缺陷，即使在最后一次SDS后1个月。这些异常与脑电图（EEG）频谱功率的变化有关，包括在亮相期间REM睡眠θ功率的降低。两种不同类型的抗抑郁药（AD），丙咪嗪和氟西汀的长期治疗，显着改善这些行为，睡眠和脑电图异常。有趣的是，REM θ功率通过长期（1个月）而不是1周AD给药正常化，并且仅与末次SDS后1个月的社会互动比率（客观指标）相关。这些数据表明，REM睡眠θ波功率（一种从未在人类中直接研究过的EEG参数）的减少是社交失败大鼠的核心睡眠症状，也可能是与压力相关的精神障碍患者的核心睡眠症状，包括重度抑郁症和创伤后应激障碍。
The effects of chronic antidepressant (AD) treatment on sleep disturbances in rodent chronic stress models have not been thoroughly investigated. Here, we show that chronic social defeat stress (SDS) in rats induces prolonged social avoidance, alterations in sleep architecture (increased total rapid eye movement [REM] sleep duration, bout, and shortened REM latency), and contextual but not cued fear memory deficits, even 1 month after the last SDS. These abnormalities were associated with changes in electroencephalography (EEG) spectral powers, including reduced REM sleep theta power during the light phase. Chronic treatment with two different classes of antidepressants (ADs), imipramine and fluoxetine, significantly ameliorated these behavioral, sleep, and EEG abnormalities. Interestingly, REM theta power was normalized by chronic (1 month) but not 1 week AD administration and solely correlated with the ratio (an objective indicator) of social interaction 1 month after the last SDS. These data suggest that reductions in REM sleep theta power, an EEG parameter that has never been directly investigated in humans, is a core sleep symptom in socially defeated rats, and, potentially, also in patients with stress-related psychiatric disorders, including major depressive and posttraumatic stress disorders.
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影响因子：
15.9
作者：
Dillon DG;Pizzagalli DA
通讯作者：
Pizzagalli DA
影响因子：
10.6
作者：
Brachman RA;McGowan JC;Perusini JN;Lim SC;Pham TH;Faye C;Gardier AM;Mendez-David I;David DJ;Hen R;Denny CA
通讯作者：
Denny CA
影响因子：
2.7
作者：
Dametto, M;Suchecki, D;Oliveira, MGM
通讯作者：
Oliveira, MGM
DOI：
10.1176/appi.ajp.2012.12040432
发表时间：
2013-04
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Germain A
通讯作者：
Germain A
影响因子：
1.3
作者：
Dulka, Brooke N.;Lynch, Joseph F., III;Jasnow, Aaron M.
通讯作者：
Jasnow, Aaron M.