Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study.
Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study.
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DOI：
10.1111/jgs.14922
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发表时间：
2017-08
影响因子：
6.3
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
McEvoy CT;Guyer H;Langa KM;Yaffe K
有证据表明，坚持地中海饮食（MedDiet）或MIND饮食具有神经保护作用，但这些饮食模式与认知之间的关联尚未在美国老年人的全国代表性人群中进行评估。基于人口的横断面研究。来自健康和退休研究的社区居住老年人（n = 5，907）。根据食物频率问卷，使用先验标准确定饮食模式的依从性，以生成MedDiet（范围= 0-55）和MIND饮食（范围0-15）的饮食评分。使用整体认知功能的复合测试评分（范围0-27）测量认知性能。线性回归被用来比较三分之一饮食模式的认知表现。采用逻辑回归分析研究饮食模式与临床显著认知功能障碍之间的关系。模型根据年龄、性别、种族、教育程度和其他健康和生活方式协变量进行调整。参与者的平均年龄为68 ± 10.8岁。在完全校正的模型中，与MedDiet评分低的受试者相比，MedDiet评分中和高分的受试者认知能力较差的可能性较小（OR 0.85; 95% CI 0.71，1.02：P = 0.08，OR 0.65; 95% CI：0.52，0.81：P < 0.001）。MIND饮食的结果相似。每种饮食模式中较高的得分与剂量反应方式（PTREND < 0.001）中显著更好的认知功能独立相关（P < 0.001）。在一个具有全国代表性的老年人群体中，更好地坚持MedDiet和MIND饮食与更好的认知功能和更低的认知障碍风险独立相关。需要临床试验来阐明饮食模式在认知老化中的作用。
Evidence suggests that adherence to the Mediterranean (MedDiet) or MIND diet is neuroprotective but the association between these dietary patterns and cognition has not been evaluated in a nationally representative population of older US adults. Population-based cross-sectional study. Community-dwelling older adults from the Health and Retirement Study (n = 5,907). Adherence to dietary patterns was determined from food frequency questionnaires using a priori criteria to generate diet scores for MedDiet (range = 0–55) and MIND diet (range 0–15). Cognitive performance was measured using a composite test score of global cognitive function (range 0–27). Linear regression was used to compare cognitive performance across tertiles of dietary pattern. Logistic regression was used to examine the association between dietary patterns and clinically significant cognitive impairment. Models were adjusted for age, gender, race, educational attainment and other health and lifestyle covariates. Mean age of participants was 68 ± 10.8 years. Compared to those with low MedDiet score, participants with mid and high score were less likely to have poor cognitive performance (OR 0.85; 95% CI 0.71, 1.02: P = 0.08, and OR 0.65; 95% CI: 0.52, 0.81: P < 0.001, respectively) in fully adjusted models. Results for the MIND diet were similar. Higher score in each dietary pattern was independently associated with significantly better cognitive function (P < 0.001) in a dose-response manner (PTREND < 0.001). In a large nationally representative population of older adults, greater adherence to the MedDiet and MIND diet was independently associated with better cognitive function and lower risk of cognitive impairment. Clinical trials are required to elucidate the role of dietary patterns in cognitive aging.
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发表时间：
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影响因子：
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发表时间：
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