The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases.
The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases.
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DOI：
10.2174/1871530314666140922153350
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Estruch R
中科院分区：
文献类型：
--
作者：
Casas R;Sacanella E;Estruch R
富含精制淀粉、糖、饱和脂肪酸和反式脂肪酸，天然抗氧化剂和水果、蔬菜和全谷物纤维含量低，ω-3脂肪酸含量低的饮食模式可能会导致先天免疫系统激活，最有可能是由于促炎细胞因子的过度产生与抗炎细胞因子的产生减少有关。地中海饮食（MedDiet）是一种受地中海盆地一些国家传统饮食模式启发的营养模式。这种饮食模式的特点是大量食用橄榄油，大量食用植物性食物（水果、蔬菜、豆类、谷物、坚果和种子）;经常和适度摄入葡萄酒（主要是在用餐时）;适量食用鱼、海鲜、酸奶、奶酪、家禽和鸡蛋;以及少量食用红肉、加工肉制品和种子。几项流行病学研究已经评估了地中海模式对与慢性低度炎症相关的几种疾病的保护作用，如癌症，糖尿病，肥胖症，动脉粥样硬化，代谢综合征和认知障碍。采用这种饮食模式可以抵消几种炎症标志物的影响，例如，减少动脉粥样硬化过程中涉及的循环和细胞生物标志物的分泌。因此，本综述的目的是考虑当前有关MedDiet在这些慢性炎症性疾病中有效性的证据，因为其抗氧化和抗炎特性不仅可能作用于经典的风险因素，而且可能作用于炎症生物标志物，例如粘附分子、细胞因子或与动脉粥样斑块稳定性相关的分子。
Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from fruits, vegetables, and whole grains, and poor in omega-3 fatty acids may cause an activation of the innate immune system, most likely by excessive production of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines. The Mediterranean Diet (MedDiet) is a nutritional model inspired by the traditional dietary pattern of some of the countries of the Mediterranean basin. This dietary pattern is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat, processed meat products and seeds. Several epidemiological studies have evaluated the effects of a Mediterranean pattern as protective against several diseases associated with chronic low-grade inflammation such as cancer, diabetes, obesity, atherosclerosis, metabolic syndrome and cognition disorders. The adoption of this dietary pattern could counter the effects of several inflammatory markers, decreasing, for example, the secretion of circulating and cellular biomarkers involved in the atherosclerotic process. Thus, the aim of this review was to consider the current evidence about the effectiveness of the MedDiet in these chronic inflammatory diseases due to its antioxidant and anti-inflammatory properties, which may not only act on classical risk factors but also on inflammatory biomarkers such as adhesion molecules, cytokines or molecules related to the stability of atheromatic plaque.
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影响因子：
3.7
作者：
Casas R;Sacanella E;Urpí-Sardà M;Chiva-Blanch G;Ros E;Martínez-González MA;Covas MI;Rosa Ma Lamuela-Raventos;Salas-Salvadó J;Fiol M;Arós F;Estruch R
通讯作者：
Estruch R
影响因子：
4.7
作者：
Fito, M.;Cladellas, M.;Covas, M. I.
通讯作者：
Covas, M. I.
影响因子：
1.2
作者：
Cottee, P.
通讯作者：
Cottee, P.
影响因子：
3.6
作者：
Camargo, Antonio;Delgado-Lista, Javier;Lopez-Miranda, Jose
通讯作者：
Lopez-Miranda, Jose
DOI：
10.1016/j.numecd.2009.08.014
发表时间：
2011-03-01
影响因子：
3.9
作者：
Athyros, V. G.;Kakafika, A. I.;Mikhailidis, D. P.
通讯作者：
Mikhailidis, D. P.