Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life
Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life
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呼吸道合胞病毒感染：其在生命头两年内空气过敏原致敏中的作用
DOI：
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发表时间：
1996
影响因子：
4.4
通讯作者：
U. Wahn
中科院分区：
文献类型：
--
作者：
J. Foister;Uta Tacke;H. Krebs;H. Streckert;H. Werchau;R. Bergmann;J. Schulz;S. Lau;U. Wahn
我们的目的是研究非住院婴儿呼吸道合胞病毒（RSV）感染对吸入性过敏原致敏和特应性早期表现的影响。纳入了来自前瞻性德国特应性多中心队列研究的609名婴儿，其中38%的婴儿具有升高的特应性风险。用梯度纯化的RSV抗原通过ELISA检测RSV IgG和IgM抗体。用CAP-RAST-FEIA（Pharmacia，Sweden）检测针对螨、猫头皮屑、桦树和草花粉以及相关营养抗原的特异性IgE。在脐带血清中，99%为RSV-IgG阳性，44.一年7%，64。2岁时为2%（n=265）。12个月后的阳性率随出生季节、兄弟姐妹人数和烟草烟雾暴露程度而变化，并与婴儿期喘息发作密切相关。二十（2. 8%）的儿童被发现在一年内对至少一种空气过敏原过敏，28（10。5%，两年。到第一个生日时，螨致敏（n=3）仅在RSV感染的儿童中可见;草花粉致敏（n=9）与RSV血清阳性相关（逻辑回归模型包括上述混杂因素：RSV IgG p=0.04 >和IgM p=0.0006），桦树致敏（n=5）与RSV IgM（p=0.009）也是如此。两年时未发现此类差异。RSV血清阳性与任何过敏性表现无相关性，我们得出结论，这是只有在生命的第一年，RSV感染起着重要的作用，促进对空气过敏原，这在这个时候不产生过敏症状的致敏。
Our aim was to study the influence of infection with the respiratory syncytial virus (RSV) in non‐hospitalized infants on sensitization to aeroallergens and the early manifestation of atopy. Six hundert and nine infants from the prospective German Multicenter Cohort Study on Atopy were included, 38% of whom had an elevated atopic risk. RSV IgG and IgM antibodies were tested by ELISA with gradient purified RSV antigen. Specific IgE against mites, cat dandruff, birch and grass pollens and relevant nutritional antigens were tested with CAP‐RAST‐FEIA (Pharmacia, Sweden). Of the cord sera 99% were positive for RSV‐IgG, 44. 7% at one year and 64. 2% (n=265) at two years of age. The positivity rate after 12 months varied with the season of birth, the number of siblings and the degree of exposure to tobacco smoke; and correlated closely with attacks of wheezing during infancy. Twenty (2. 8%) children were found to be sensitized against at least one aeroallergen at one year, and 28 (10. 5%) at two years. By the first birthday, mite sensitization (n=3) could only be seen in the RSV‐infected children; grass pollen sensitization (n=9) was associated with RSV seropositivity (logistic regression model including the confounders mentioned above: with RSV IgG p=0.04 > and IgM p=0.0006), as was birch sensitization (n=5) with RSV IgM (p=0.009). No such differences could be detected at two years. No correlation of RSV seropositivity to any allergic manifestation could be found. We conclude, that it is only in the first year of life, that RSV infection plays a significant role in promoting sensitization against aeroallergens, which do not at this time produce allergic symptoms.
呼吸道合胞病毒特异性 IgE 反应对细支气管炎后复发性喘息的预测价值。
DOI：
10.1016/s0022-3476(86)80692-8
发表时间：
1986
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Welliver,RC;Sun,M;Rinaldo,D;Ogra,PL
通讯作者：
Ogra,PL
儿童早期呼吸道感染与支气管反应性和过敏性水平升高的关系。
DOI：
10.1164/arrd.1985.131.4.573
发表时间：
1985
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Weiss,ST;Tager,IB;Munoz,A;Speizer,FE
通讯作者：
Speizer,FE