A bibliometric review of drug repurposing.

A bibliometric review of drug repurposing.
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DOI:
10.1016/j.drudis.2018.01.018
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发表时间:
2018-03
影响因子:
7.4
通讯作者:
Tropsha A
Tropsha A
中科院分区:
医学2区
文献类型:
--
作者:
Baker NC;Ekins S;Williams AJ;Tropsha A

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我们通过扫描PubMed中超过2500万篇论文,并使用文本挖掘方法收集,计算和分析化学疾病治疗关系,对药物再利用进行了文献计量学审查。我们发现,在我们研究中确定的约35000种药物或候选药物中,有超过60%已在一种以上的疾病中进行过试验,其中189种药物已在300种以上的疾病中进行过试验。虽然在大多数情况下,这些药物被应用于接近其原始用途的治疗领域,但已经有了引人注目的,也许是有启发性的,成功的尝试将药物重新用于意想不到的新治疗领域。
We have conducted a bibliometric review of drug repurposing by scanning >25 million papers in PubMed and using text-mining methods to gather, count and analyze chemical–disease therapeutic relationships. We find that >60% of the ~35 000 drugs or drug candidates identified in our study have been tried in more than one disease, including 189 drugs that have been tried in >300 diseases each. Whereas in the majority of cases these drugs were applied in therapeutic areas close to their original use, there have been striking, and perhaps instructive, successful attempts of drug repurposing for unexpected, novel therapeutic areas.
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