Fear learning enhances neural responses to threat-predictive sensory stimuli.
Fear learning enhances neural responses to threat-predictive sensory stimuli.
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DOI：
10.1126/science.1244916
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发表时间：
2013-12-13
期刊：
影响因子：
--
通讯作者：
McGann JP
中科院分区：
文献类型：
--
作者：
Kass MD;Rosenthal MC;Pottackal J;McGann JP
The central nervous system rapidly learns that particular stimuli predict imminent danger. This learning is thought to involve associations between neutral and harmful stimuli in cortical and limbic brain regions, though associative neuroplasticity in sensory structures is increasingly appreciated. We observed the synaptic output of olfactory sensory neurons (OSNs) in individual mice before and after they learned that a particular odor indicated an impending footshock. OSNs are the first cells in the olfactory system, physically contacting the odor molecules in the nose and projecting their axons to the brain’s olfactory bulb. Surprisingly, OSN output evoked by the shock-predictive odor was selectively facilitated after fear conditioning. These results indicate that affective information about stimuli can be encoded in their very earliest representations in the nervous system.
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