Associative fear learning enhances sparse network coding in primary sensory cortex.
Associative fear learning enhances sparse network coding in primary sensory cortex.
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DOI：
10.1016/j.neuron.2012.04.035
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发表时间：
2012-07-12
期刊：
影响因子：
16.2
通讯作者：
Trachtenberg JT
中科院分区：
文献类型：
--
作者：
Gdalyahu A;Tring E;Polack PO;Gruver R;Golshani P;Fanselow MS;Silva AJ;Trachtenberg JT
联想学习的几个模型预测了在联想形成过程中刺激加工的变化。联想学习如何重新配置初级感觉皮层的神经回路以“学习”刺激的联想属性仍然未知。利用双光子体内钙成像技术测量初级体感觉皮层神经元网络的反应，我们发现，须刺激与足部电击相结合的联想恐惧学习增强了条件刺激的稀疏种群编码和鲁棒性，但降低了总网络活动。与对照组相比，较少的皮层神经元对训练后的须的刺激作出反应，但它们的反应强度增强了。这些反应在暴露于非联想学习过程的小鼠中没有观察到。我们的研究结果定义了联想恐惧学习如何塑造感觉刺激的皮层表征。这些变化是为了提高联想学习后的感觉加工效率。
Several models of associative learning predict that stimulus processing changes during association formation. How associative learning reconfigures neural circuits in primary sensory cortex to "learn" associative attributes of a stimulus remains unknown. Using 2-photon in-vivo calcium imaging to measure responses of networks of neurons in primary somatosensory cortex, we discovered that associative fear learning, in which whisker stimulation is paired with foot shock, enhances sparse population coding and robustness of the conditional stimulus, yet decreases total network activity. Fewer cortical neurons responded to stimulation of the trained whisker than in controls, yet their response strength was enhanced. These responses were not observed in mice exposed to a non-associative learning procedure. Our results define how the cortical representation of a sensory stimulus is shaped by associative fear learning. These changes are proposed to enhance efficient sensory processing after associative learning.
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