Voxel-based morphometric gray matter correlates of posttraumatic stress disorder.
Voxel-based morphometric gray matter correlates of posttraumatic stress disorder.
复制标题
DOI：
10.1016/j.janxdis.2013.04.004
复制
发表时间：
2013-05
影响因子：
10.3
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
--
作者：
Weber, Mareen;Killgore, William D. S.;Rosso, Isabelle M.;Britton, Jennifer C.;Schwab, Zachary J.;Weiner, Melissa R.;Simon, Naomi M.;Pollack, Mark H.;Rauch, Scott L.
关键词：
创伤后应激障碍（PTSD）与包括海马体、杏仁核和内侧前额皮质在内的神经回路功能异常有关。然而，这些区域的结构异常及其与PTSD严重程度和症状负担的关系的证据很少。本研究采用基于体素的形态学方法评价脑灰质体积指标与PTSD症状严重程度的关系。15名符合DSM-IV PTSD标准的患者完成了临床医师管理的PTSD量表，并进行了结构磁共振成像。更严重的创伤后应激障碍和逃避/麻木与右侧杏仁核-海马复合体的灰质体积增加有关。更大的过度觉醒与左侧内侧额上回灰质体积减少有关。研究结果与目前PTSD的神经回路模型一致，该模型假设该疾病与该分布式网络中的结构和功能变异有关。
Posttraumatic stress disorder (PTSD) is associated with functional abnormalities within aneurocircuitry that includes the hippocampus, amygdala, and medial prefrontal cortex. Evidence of structural abnormalities within these regions, and their association with PTSD severity and symptom burden is, however, sparse. The present study evaluated the relation between indices of gray matter volume and PTSD symptom severity using voxel-based morphometry. Fifteen individuals meeting DSM-IV criteria for PTSDcompleted the Clinician Administered PTSD Scale and underwent structural magnetic resonance imaging. Greater PTSD severity and avoidance/numbing were correlated withincreasedgray matter volume of the right amygdala-hippocampal complex. Greater hyper-arousal was associated with reducedgray matter volume in the left superior medial frontal gyrus. Findings are consistent with current neurocircuitry models of PTSD, which posit that the disorder is associated with structural and functional variance within this distributed network.
登录
查看更多内容
影响因子：
2.1
作者：
Chen SN;Ballantyne CM;Gotto AM Jr;Marian AJ
通讯作者：
Marian AJ
影响因子：
10.6
作者：
Kasai, Kiyoto;Yamasue, Hidenori;Pitman, Roger K.
通讯作者：
Pitman, Roger K.
影响因子：
4.8
作者：
Baldacara, Leonardo;Jackowski, Andrea P.;Bressan, Rodrigo A.
通讯作者：
Bressan, Rodrigo A.
影响因子：
4.3
作者：
Eckart, Cindy;Stoppel, Christian;Kolassa, Iris-Tatjana
通讯作者：
Kolassa, Iris-Tatjana
影响因子：
5.7
作者：
Geuze, Elbert;Westenberg, Herman G. M.;Vermetten, Eric
通讯作者：
Vermetten, Eric