Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.
Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.
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DOI：
10.1016/j.biopsych.2017.09.006
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发表时间：
2018-02-01
影响因子：
10.6
通讯作者：
Morey RA
中科院分区：
文献类型：
--
作者：
Logue MW;van Rooij SJH;Dennis EL;Davis SL;Hayes JP;Stevens JS;Densmore M;Haswell CC;Ipser J;Koch SBJ;Korgaonkar M;Lebois LAM;Peverill M;Baker JT;Boedhoe PSW;Frijling JL;Gruber SA;Harpaz-Rotem I;Jahanshad N;Koopowitz S;Levy I;Nawijn L;O'Connor L;Olff M;Salat DH;Sheridan MA;Spielberg JM;van Zuiden M;Winternitz SR;Wolff JD;Wolf EJ;Wang X;Wrocklage K;Abdallah CG;Bryant RA;Geuze E;Jovanovic T;Kaufman ML;King AP;Krystal JH;Lagopoulos J;Bennett M;Lanius R;Liberzon I;McGlinchey RE;McLaughlin KA;Milberg WP;Miller MW;Ressler KJ;Veltman DJ;Stein DJ;Thomaes K;Thompson PM;Morey RA
Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen’s d = −0.17, p = .00054), and smaller amygdalae (d = −0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063). Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain’s response to trauma.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
11.3
作者：
Herringa R;Phillips M;Almeida J;Insana S;Germain A
通讯作者：
Germain A
影响因子：
4.4
作者：
Goldstein RB;Smith SM;Chou SP;Saha TD;Jung J;Zhang H;Pickering RP;Ruan WJ;Huang B;Grant BF
通讯作者：
Grant BF
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
6.6
作者：
Kitayama, N;Vaccarino, V;Bremner, JD
通讯作者：
Bremner, JD