Effect of recombinant human epidermal growth factor against cutaneous scar formation in murine full-thickness wound healing.
Effect of recombinant human epidermal growth factor against cutaneous scar formation in murine full-thickness wound healing.
复制标题
重组人表皮生长因子对小鼠全层伤口愈合中皮肤疤痕形成的影响。
DOI：
10.3346/jkms.2010.25.4.589
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发表时间：
2010-04
影响因子：
4.5
通讯作者：
Hong JP
中科院分区：
文献类型：
--
作者：
Kim YS;Lew DH;Tark KC;Rah DK;Hong JP
皮肤上可见的疤痕是由于炎症反应导致未成熟的胶原蛋白过度形成。本研究探讨了表皮生长因子(EGF)在皮肤瘢痕形成中的作用。选用20只CRL：CD-1(ICR)小鼠，每只小鼠背部造成2个全层皮肤创面。其中一个创面局部涂抹重组人EGF，另一个创面用生理盐水治疗，直至完全愈合。EGF组创面愈合快于对照组，瘢痕宽度缩小30%，面积缩小26%。EGF治疗组的炎性细胞数量明显减少。表皮生长因子治疗组大鼠肺组织转化生长因子-β-1表达增强。观察到EGF处理组的胶原含量明显高于对照组。在EGF治疗组中，可见的外部瘢痕比对照组要少。提示表皮生长因子可能通过抑制炎症反应，减少转化生长因子-β-1的表达，介导胶原的形成，从而减轻皮肤瘢痕。
A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the formation of cutaneous scars. Twenty Crl:CD-1 (ICR) mice were used and 2 full-thickness skin wounds were made on the dorsum of each mouse. One of the wounds was treated with recombinant human EGF by local application and the other was treated with saline for control until complete healing was achieved. The EGF-treated group's wounds healed faster than the control group's. The width of the scar was smaller by 30% and the area was smaller by 26% in the EGF-treated group. Inflammatory cell numbers were significantly lower in the EGF-treated group. The expression of transforming growth factor (TGF)-β1 in the EGF-treated group was increased. It was observed that the amount of collagen in the EGF-treated group was larger than the control group. In the EGF-treated group, the visible external scars were less noticeable than that in the control group. These results suggest that EGF can reduce cutaneous scars by suppressing inflammatory reactions, decreasing expression of TGF-β1, and mediating the formation of collagen.
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影响因子：
3.5
作者：
Babül, A;Gönül, B;Özogul, C
通讯作者：
Özogul, C
影响因子：
2.4
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LONGAKER, MT;WHITBY, DJ;HARRISON, MR
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9
作者：
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通讯作者：
ADZICK, NS