Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand.
Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand.
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来自新西兰奥克兰的病例对照人群中的硒，硒蛋白基因和克罗恩病。
DOI：
10.3390/nu4091247
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发表时间：
2012-09
期刊：
影响因子：
5.9
通讯作者：
Ferguson LR
中科院分区：
文献类型：
--
作者：
Gentschew L;Bishop KS;Han DY;Morgan AR;Fraser AG;Lam WJ;Karunasinghe N;Campbell B;Ferguson LR
新西兰是克罗恩病（CD）发病率最高的国家之一，而新西兰人的血清硒水平是世界上最低的。新西兰奥克兰的一项前瞻性病例对照研究认为血清硒是潜在的乳糜泻危险因素。与对照组相比，CD患者血清硒水平显著降低（101.8±1.02 vs 111.1±1.01 ng/mL） （p = 5.91 × 10−8）。最近在英国的详细研究表明，最佳血清水平约为122 ng/mL，这使得新西兰的普通CD患者硒缺乏。在检测的29个单核苷酸多态性（snp）中，发现13个与CD上的血清硒显著相互作用。经多次检测调整后，发现3个snp与CD上的血清硒显著相互作用，即SEPHS1基因的rs17529609和rs7901303，以及SEPSECS基因的rs1553153。这三种snp在其他地方未见与硒或乳糜泻显著相关的报道。目前尚不清楚低硒水平是该疾病的原因还是结果。
New Zealand has one of the highest incidence rates of Crohn’s Disease (CD), whilst the serum selenium status of New Zealanders is amongst the lowest in the world. A prospective case-control study in Auckland, New Zealand considered serum selenium as a potential CD risk factor. Serum selenium levels were significantly lower in CD patients compared to controls (101.8 ± 1.02 vs. 111.1 ± 1.01 ng/mL) (p = 5.91 × 10−8). Recent detailed studies in the United Kingdom have suggested an optimal serum level around 122 ng/mL, making the average CD patient in New Zealand selenium deficient. Of the 29 single nucleotide polymorphisms (SNPs) tested, 13 were found to significantly interact with serum selenium on CD. After adjustment for multiple testing, a significant interaction with serum selenium on CD was found for three SNPs, namely rs17529609 and rs7901303 in the gene SEPHS1, and rs1553153 in the gene SEPSECS. These three SNPs have not been reported elsewhere as being significantly associated with selenium or CD. It is unclear as to whether lower selenium levels are a cause or an effect of the disease.
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影响因子：
2.9
作者：
Foster CB;Aswath K;Chanock SJ;McKay HF;Peters U
通讯作者：
Peters U
影响因子：
38.9
作者：
Berger, MM;Reymond, MJ;Chioléro, RL
通讯作者：
Chioléro, RL
影响因子：
6.6
作者：
Koenig, RJ
通讯作者：
Koenig, RJ
DOI：
10.1016/j.bbrc.2010.05.055
发表时间：
2010-06-18
影响因子：
3.1
作者：
Kim, Jin Young;Lee, Kwang Hee;Shim, Myoung Sup;Shin, Hyein;Xu, Xue-Ming;Carlson, Bradley A.;Hatfield, Dolph L.;Lee, Byeong Jae
通讯作者：
Lee, Byeong Jae
影响因子：
4.8
作者：
Boelen, A;Kwakkel, J;Visser, TJ
通讯作者：
Visser, TJ