The neuronal correlates of intranasal trigeminal function-an ALE meta-analysis of human functional brain imaging data.
The neuronal correlates of intranasal trigeminal function-an ALE meta-analysis of human functional brain imaging data.
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DOI：
10.1016/j.brainresrev.2009.11.001
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发表时间：
2010-03
影响因子：
--
通讯作者：
Lundström JN
中科院分区：
文献类型：
--
作者：
Albrecht J;Kopietz R;Frasnelli J;Wiesmann M;Hummel T;Lundström JN
我们在日常生活中遇到的几乎每一种气味都能产生三叉神经感觉。令人惊讶的是，很少有功能成像研究探索鼻内三叉神经功能与人类神经元的相关性，而且结果在某种程度上是不一致的。我们利用激活似然估计(ALE)，一种基于体素的定量元分析工具，分析了二氧化碳(CO2)鼻内刺激三叉神经后的功能成像数据(fMRI/PET)，二氧化碳是一种已知的专门激活三叉神经系统的刺激。元分析工具能够识别研究中常见的激活，从而能够以更高的确定性进行激活映射。9项利用三叉神经刺激的研究的激活焦点被纳入荟萃分析。我们在脑干、丘脑腹外侧核、前扣带回、脑岛、中央前回以及初级和次级躯体感觉皮质--一个以处理鼻内伤害性刺激而闻名的网络--发现了显著的ALE评分，从而表明在所有研究中都有一致的激活。在梨状皮质、脑岛和眶前叶皮质也观察到了显著的ALE值，这些区域是已知的处理化学感觉刺激的区域，以及联合皮质。此外，三叉神经的ALE统计数据直接与源于嗅觉刺激的ALE统计数据进行比较，显示出相当大的激活重叠。总之，这一荟萃分析的结果以很高的统计确定性绘制了三叉神经鼻内刺激与人类神经元的关系图，并表明在处理鼻内二氧化碳刺激的过程中招募的皮质区域包括传统三叉神经区以外的区域。此外，通过对处理三叉神经和嗅觉信息的大脑区域之间相当大的重叠的说明，这些结果证明了风味处理的相互联系。
Almost every odor we encounter in daily life has the capacity to produce a trigeminal sensation. Surprisingly, few functional imaging studies exploring human neuronal correlates of intranasal trigeminal function exist, and results are to some degree inconsistent. We utilized activation likelihood estimation (ALE), a quantitative voxel-based meta-analysis tool, to analyze functional imaging data (fMRI/PET) following intranasal trigeminal stimulation with carbon dioxide (CO2), a stimulus known to exclusively activate the trigeminal system. Meta-analysis tools are able to identify activations common across studies, thereby enabling activation mapping with higher certainty. Activation foci of nine studies utilizing trigeminal stimulation were included in the meta-analysis. We found significant ALE scores, thus indicating consistent activation across studies, in the brainstem, ventrolateral posterior thalamic nucleus, anterior cingulate cortex, insula, precentral gyrus, as well as in primary and secondary somatosensory cortices – a network known for the processing of intranasal nociceptive stimuli. Significant ALE values were also observed in the piriform cortex, insula, and the orbitofrontal cortex, areas known to process chemosensory stimuli, and in association cortices. Additionally, the trigeminal ALE statistics were directly compared with ALE statistics originating from olfactory stimulation, demonstrating considerable overlap in activation. In conclusion, the results of this meta-analysis map the human neuronal correlates of intranasal trigeminal stimulation with high statistical certainty and demonstrate that the cortical areas recruited during the processing of intranasal CO2 stimuli include those outside traditional trigeminal areas. Moreover, through illustrations of the considerable overlap between brain areas that process trigeminal and olfactory information; these results demonstrate the interconnectivity of flavor processing.
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