Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study.
Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study.
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DOI：
10.1093/cid/ciy677
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发表时间：
2019-04-08
期刊：
影响因子：
--
通讯作者：
Rimoin AW
中科院分区：
文献类型：
--
作者：
Kelly JD;Hoff NA;Spencer D;Musene K;Bramble MS;McIlwain D;Okitundu D;Porco TC;Rutherford GW;Glymour MM;Bjornson Z;Mukadi P;Okitolonda-Wemakoy E;Nolan GP;Muyembe-Tamfum JJ;Rimoin AW
在埃博拉疫情爆发20多年后，与密切接触者相比，埃博拉幸存者的认知得分更低，抑郁和焦虑症状更多，这表明这些地区是10000西非埃博拉幸存者的潜在长期需求。埃博拉病毒病(EVD)的临床后遗症在疫情爆发后3年多没有得到描述。我们检查了1995年刚果民主共和国Kikwit埃博拉疫情的幸存者和密切接触者，确定了神经、认知和心理异常发现的流行率及其与埃博拉病毒存活率的关系。2017年8月至9月，我们在刚果(金)基奎特进行了一项横断面研究。在埃博拉病毒病爆发20多年后，我们招募了埃博拉病毒病幸存者和疫情中的密切接触者进行体检，并接受了Folstein迷你精神状态检查(MMSE)和Goldberg焦虑和抑郁量表(GADS)的文化适应版本。我们通过比较幸存者和密切接触者，并根据年龄、性别、教育水平、婚姻状况和医护人员状况进行调整，使用线性回归模型估计了EVD存活率和健康结果之间的关系强度。我们招募了20名埃博拉病毒幸存者和187名密切接触者。在20例EVD幸存者中，4例(20%)报告了至少一种异常的神经症状，3例(15%)有异常的神经检查。在187名密切接触者中，14名(11%)有至少1项神经症状，9名(5%)有神经检查异常。与密切接触者相比，EVD幸存者的平均MMSE较低，GADS得分较高(MMSE：调整系数：−1.85；95%可信区间[CI]：−3.63，−0.07；GADS：调整系数：3.91；95%CI：1.76，6.04)。埃博拉病毒爆发20多年后，与密切接触者相比，埃博拉病毒幸存者的认知得分更低，抑郁和焦虑症状更多。
Ebola survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after an outbreak, suggesting these areas as potential long-term needs for >10000 West African Ebola survivors. Clinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined prevalence of abnormal neurological, cognitive, and psychological findings and their association with EVD survivorship. From August to September 2017, we conducted a cross-sectional study in Kikwit, DRC. Over 2 decades after the EVD outbreak, we recruited EVD survivors and close contacts from the outbreak to undergo physical examination and culturally adapted versions of the Folstein mini-mental status exam (MMSE) and Goldberg anxiety and depression scale (GADS). We estimated the strength of relationships between EVD survivorship and health outcomes using linear regression models by comparing survivors versus close contacts, adjusting for age, sex, educational level, marital status, and healthcare worker status. We enrolled 20 EVD survivors and 187 close contacts. Among the 20 EVD survivors, 4 (20%) reported at least 1 abnormal neurological symptom, and 3 (15%) had an abnormal neurological examination. Among the 187 close contacts, 14 (11%) reported at least 1 abnormal neurologic symptom, and 9 (5%) had an abnormal neurological examination. EVD survivors had lower mean MMSE and higher mean GADS scores as compared to close contacts (MMSE: adjusted coefficient: −1.85; 95% confidence interval [CI]: −3.63, −0.07; GADS: adjusted coefficient: 3.91; 95% CI: 1.76, 6.04). EVD survivors can have lower cognitive scores and more symptoms of depression and anxiety than close contacts more than 2 decades after Ebola virus outbreaks.
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影响因子：
15.8
作者：
Betancourt TS;Brennan RT;Vinck P;VanderWeele TJ;Spencer-Walters D;Jeong J;Akinsulure-Smith AM;Pham P
通讯作者：
Pham P
影响因子：
105.7
作者：
GOLDBERG, D;BRIDGES, K;GRAYSON, D
通讯作者：
GRAYSON, D
影响因子：
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Khan, AS;Tshioko, FK;Ksiazek, TG
通讯作者：
Ksiazek, TG
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33.9
作者：
McNamara, Lucy A.;Schafer, Ilana J.;Knust, Barbara
通讯作者：
Knust, Barbara
影响因子：
6.4
作者：
Kibadi, K;Mupapa, K;Colebunders, R
通讯作者：
Colebunders, R