Frontal white matter integrity predictors of adult alcohol treatment outcome.
Frontal white matter integrity predictors of adult alcohol treatment outcome.
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成人酒精治疗结果的额叶白质完整性预测指标。
DOI：
10.1016/j.biopsych.2011.09.022
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发表时间：
2012-02-01
影响因子：
10.6
通讯作者：
Grant, Igor
中科院分区：
文献类型：
--
作者：
Sorg, Scott F.;Taylor, Michael J.;Alhassoon, Omar M.;Gongvatana, Assawin;Theilmann, Rebecca J.;Frank, Lawrence R.;Grant, Igor
Previous research has associated abnormalities in frontal lobe functioning with alcohol relapse. In this study, we used diffusion tensor imaging to investigate whether frontal white matter integrity measured at the start of treatment differs between persons with alcohol use disorders (AUD) who sustain treatment gains and those who return to heavy use after treatment. Forty-five treatment-seeking AUD inpatients and 30 healthy control subjects were included in the study. Six months after completing treatment, 16 of the AUD participants had resumed heavy use (RHU) and 29 others remained abstinent or drank minimally (treatment sustainers [TS]). Voxel-wise group comparisons (TS vs. RHU) were performed on fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity maps generated from each subject’s diffusion tensor imaging scan at the start of treatment. We found significantly lower FA and significantly higher RD in the frontal lobes of the RHU group, relative to the TS group. The RHU group data are consistent with previous reports of abnormal frontal white matter tract abnormalities in persons with AUD. It is possible that the lower FA and higher RD in the RHU group reflect microstructural injury to frontal circuitries, and these may underlie the reduced cognitive control amid heightened reward sensitivity associated with resumption of heavy drinking.
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DOI：
10.1097/00000374-200204000-00017
发表时间：
2002-04-01
影响因子：
3.2
作者：
Fein, G;Di Sclafani, V;Meyerhoff, DJ
通讯作者：
Meyerhoff, DJ
影响因子：
6
作者：
Allsop, S;Saunders, B;Phillips, M
通讯作者：
Phillips, M
DOI：
10.1111/j.1530-0277.2007.00406.x
发表时间：
2007-07-01
影响因子：
3.2
作者：
Heinz, Andreas;Wrase, Jana;Mann, Karl
通讯作者：
Mann, Karl
DOI：
10.1111/j.1530-0277.2011.01452.x
发表时间：
2011-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
通讯作者：
Meyerhoff DJ
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR