Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence.
Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence.
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DOI：
10.1111/j.1530-0277.2011.01452.x
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Meyerhoff DJ
中科院分区：
文献类型：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
至少有60%的酒精使用障碍患者会复发。对大脑奖励系统（BRS）完整性的实证研究对于理解复发机制至关重要，因为这些回路的集合与所有形式的成瘾性疾病的发展和维持有关。本研究比较了不吸烟轻度饮酒对照组（对照组）、保持禁欲的个体和治疗后复发的个体的BRS新皮质组分的厚度、表面积和体积。75名寻求治疗的酒精依赖者（戒酒7 ± 3天）和43名对照者完成了1.5T质子磁共振成像研究。获得了BRS以下双侧组成部分的分组形态数据：喙和尾侧前扣带回皮质、前额叶、内侧和外侧眶额皮质、喙和尾侧额中回和上级回、杏仁核和海马以及其他26个双侧新皮质区域。在基线研究后对酒精依赖参与者进行了12个月的随访，并在随访时将其分类为戒酒者（无酒精消费; n=24）和复发者（任何酒精消费; n=51）。与对照组相比，复发者和戒断者在绝大多数BRS区域表现出较低的皮质厚度以及较低的整体厚度。复发者的总BRS表面积低于对照组和戒断者，但戒断者与对照组在任何表面积测量上均无显著差异。复发者在大多数区域表现出比对照组更低的体积，而戒断者在双侧的上级额回、杏仁核和海马中表现出比对照组更低的体积。复发者在右侧额中回和额中回尾侧和双侧眶额外侧皮质的体积比戒断者小。在复发者中，多个区域的基线体积和表面积较低与治疗后饮酒量较大相关。结果表明，复发者在参与内驱力状态、情绪、奖励处理和行为的“自上而下”调节/调节的区域表现出形态异常，这可能会增加复发/缓解周期的风险，从而困扰许多AUD患者。结果还强调了检查皮质厚度和表面积的重要性，以更好地了解在AUD中经常观察到的区域体积损失的性质。这份报告的结果与先前的研究一致，这些研究暗示了可塑性神经生物学变化，即大脑奖励系统在维持成瘾性疾病中的作用。
At least 60% of those treated for an alcohol use disorder will relapse. Empirical study of the integrity of the brain reward system (BRS) is critical to understanding the mechanisms of relapse as this collection of circuits is implicated in the development and maintenance of all forms of addictive disorders. This study compared thickness, surface area and volume in neocortical components of the BRS among non-smoking light drinking controls (Controls), individuals who remained abstinent and those who relapsed after treatment. Seventy-five treatment-seeking alcohol dependent individuals (abstinent for 7 ± 3 days) and 43 Controls completed 1.5T proton magnetic resonance imaging studies. Parcellated morphological data was obtained for following bilateral components of the BRS: rostral and caudal anterior cingulate cortex, insula, medial and lateral orbitofrontal cortex, rostral and caudal middle and superior frontal gyri, amygdala and hippocampus as well as for 26 other bilateral neocortical regions. Alcohol dependent participants were followed over 12-months after baseline study and were classified as Abstainers (no alcohol consumption; n=24) and Relapsers (any alcohol consumption; n=51) at follow-up. Relapsers and Abstainers demonstrated lower cortical thickness in the vast majority of BRS regions as well as lower global thickness compared to Controls. Relapsers had lower total BRS surface area than both Controls and Abstainers, but Abstainers were not significantly different from Controls on any surface area measure. Relapsers demonstrated lower volumes than Controls in the majority of regions, while Abstainers showed lower volumes than Controls in the superior frontal gyrus, insula, amygdala and hippocampus, bilaterally. Relapsers exhibited smaller volumes than Abstainers in the right rostral middle and caudal middle frontal gyri and the lateral orbitofrontal cortex, bilaterally. In Relapsers, lower baseline volumes and surface areas in multiple regions were associated with a greater magnitude of post-treatment alcohol consumption. Results suggest Relapsers demonstrated morphological abnormalities in regions involved in the “top down” regulation/modulation of internal drive states, emotions, reward processing and behavior, which may impart increased risk for the relapse/remit cycle that afflicts many with an AUD. Results also highlight the importance of examining both cortical thickness and surface area to better understand the nature of regional volume loss frequently observed in AUD. Results from this report are consistent with previous research implicating plastic neurobiological changes the brain reward system in the maintenance of addictive disorders.
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影响因子：
3.4
作者：
Delucchi, Kevin L.;Weisner, Constance
通讯作者：
Weisner, Constance
DOI：
10.1111/j.1530-0277.2007.00406.x
发表时间：
2007-07-01
影响因子：
3.2
作者：
Heinz, Andreas;Wrase, Jana;Mann, Karl
通讯作者：
Mann, Karl
影响因子：
2.8
作者：
Fabricius, Katrine;Pakkenberg, Henning;Pakkenberg, Bente
通讯作者：
Pakkenberg, Bente
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
3.9
作者：
Bottlender, M;Soyka, M
通讯作者：
Soyka, M