Novel anti-infective compounds from marine bacteria.
Novel anti-infective compounds from marine bacteria.
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DOI：
10.3390/md8030498
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发表时间：
2010-03-05
期刊：
影响因子：
5.4
通讯作者：
Schweizer M
中科院分区：
文献类型：
--
作者：
Rahman H;Austin B;Mitchell WJ;Morris PC;Jamieson DJ;Adams DR;Spragg AM;Schweizer M
由于微生物病原体不断进化出抗生素抗性，因此需要开发新的有效的抗菌化合物。自 20 世纪 60 年代以来，科学文献积累了许多关于由多种海洋细菌产生的新型药物化合物的出版物。事实上，海洋微生物仍然是天然产物研究的富有成果和成功的焦点，许多新分离的化合物具有潜在的有价值的药理活性。在这方面，海洋环境无疑将被证明是新型抗菌代谢物日益重要的来源，并且选择性或有针对性的方法已经能够回收大量产生抗生素的微生物。本次综述的目的是考虑在从海洋细菌中提取的新的次生代谢物的发现方面取得的进展，特别是那些对所谓的“超级细菌”有效的物质，包括耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE），这些细菌是导致医院感染（即院内感染）数量增加的主要原因。
As a result of the continuous evolution of microbial pathogens towards antibiotic-resistance, there have been demands for the development of new and effective antimicrobial compounds. Since the 1960s, the scientific literature has accumulated many publications about novel pharmaceutical compounds produced by a diverse range of marine bacteria. Indeed, marine micro-organisms continue to be a productive and successful focus for natural products research, with many newly isolated compounds possessing potentially valuable pharmacological activities. In this regard, the marine environment will undoubtedly prove to be an increasingly important source of novel antimicrobial metabolites, and selective or targeted approaches are already enabling the recovery of a significant number of antibiotic-producing micro-organisms. The aim of this review is to consider advances made in the discovery of new secondary metabolites derived from marine bacteria, and in particular those effective against the so called “superbugs”, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE), which are largely responsible for the increase in numbers of hospital acquired, i.e., nosocomial, infections.
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DOI：
10.1126/science.1176667
发表时间：
2009-08-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fischbach MA;Walsh CT
通讯作者：
Walsh CT
影响因子：
5.4
作者：
Chen He-Ru;Guo Xi-Kun;Zhong Xian-Bin
通讯作者：
Zhong Xian-Bin
影响因子：
1.8
作者：
Gerard, J;Haden, P;Andersen, RJ
通讯作者：
Andersen, RJ
影响因子：
5.2
作者：
Hanaki, H;Labischinski, H;Hiramatsu, K
通讯作者：
Hiramatsu, K
影响因子：
5.1
作者：
Carlson, Jacob C.;Li, Shengying;Burr, Douglas A.;Sherman, David H.
通讯作者：
Sherman, David H.