Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children.
Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children.
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DOI：
10.1002/ajmg.b.32924
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发表时间：
2023-07
影响因子：
2.8
通讯作者：
Dietrich, Andrea
中科院分区：
文献类型：
--
作者：
Abdulkadir, Mohamed;Tischfield, Jay A.;Heiman, Gary A.;Hoekstra, Pieter J.;Dietrich, Andrea
关键词：
多发性抽动症(TS)是多种遗传和环境因素共同作用的结果。然而，人们对这些因素在抽搐发生中的相互作用知之甚少。在雅芳亲子纵向研究中，我们调查了TS和妊娠相关因素的多基因风险评分(PR)是否共同增加了抽动发生率的解释方差(N病例=612；N对照=4,201；50%男性；平均年龄13.8岁)。我们包括了累积的不良妊娠风险评分，母亲的焦虑和抑郁，以及母亲在怀孕期间吸烟和饮酒。我们使用多变量方法研究了遗传和妊娠相关危险因素可能的联合作用，并探索了妊娠相关危险因素之间的中介作用，以解释抽动的存在。与仅包括PR的模型相比，PR和累积不良妊娠风险评分、母亲焦虑或母亲抑郁显著更多地解释抽动发生率的差异。此外，我们发现，累积的不良妊娠风险评分中介了几个与怀孕相关的因素(母亲焦虑、抑郁和吸烟)与抽搐之间的关系。与单独研究这些因素相比，在一般人群队列中，与单独研究这些因素相比，与单独研究这些因素相比，PRS和与怀孕相关的危险因素的组合可以解释更多的抽搐。
Tourette syndrome (TS) is caused by multiple genetic and environmental factors. Yet, little is known about the interplay of these factors in the occurrence of tics. We investigated whether polygenic risk score (PRS) of TS and pregnancy-related factors together enhance the explained variance of tic occurrence in the Avon Longitudinal Study of Parents and Children (Ncases= 612; Ncontrols=4,201; 50% male; mean age 13.8 years). We included a cumulative adverse pregnancy risk score, maternal anxiety and depression, and maternal smoking and alcohol use during pregnancy. We investigated possible joint effects of genetic and pregnancy-related risk factors using a multivariable approach, and explored mediation effects between the pregnancy-related risk factors in explaining tic presence. The PRS and the cumulative adverse pregnancy risk score, maternal anxiety, or maternal depression explained significantly more variance of tic presence compared to models including only the PRS. Furthermore, we found that the cumulative adverse pregnancy risk score mediated the association between several pregnancy-related factors (maternal anxiety, depression, and smoking) and tics. The combination of a PRS and pregnancy-related risk factors explained more variance of tics in a general population cohort compared to studying these factors in isolation.
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影响因子：
120.7
作者：
ANDA, RF;WILLIAMSON, DF;REMINGTON, PL
通讯作者：
REMINGTON, PL
影响因子：
5
作者：
England, LJ;Levine, RJ;Catalano, PM
通讯作者：
Catalano, PM
DOI：
10.1111/j.2044-8341.1988.tb02787.x
发表时间：
1988-09-01
期刊：
BRITISH JOURNAL OF MEDICAL PSYCHOLOGY
影响因子：
--
作者：
BIRTCHNELL, J;EVANS, C;KENNARD, J
通讯作者：
KENNARD, J
Tourette综合征的产前危险因素：系统评价。
影响因子：
3.1
作者：
Chao TK;Hu J;Pringsheim T
通讯作者：
Pringsheim T
影响因子：
5.8
作者：
Golding, J
通讯作者：
Golding, J