Prenatal risk factors for Tourette Syndrome: a systematic review.
Prenatal risk factors for Tourette Syndrome: a systematic review.
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Tourette综合征的产前危险因素：系统评价。
DOI：
10.1186/1471-2393-14-53
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发表时间：
2014-01-30
影响因子：
3.1
通讯作者：
Pringsheim T
中科院分区：
文献类型：
--
作者：
Chao TK;Hu J;Pringsheim T
抽动秽语综合征 (TS) 似乎是一种遗传性疾病，尽管只有不到 1% 的患者存在基因异常，且遗传方式尚不确定。许多研究调查了可能导致抽动和相关合并症（例如强迫症（OCD）和注意力缺陷多动障碍（ADHD））的发作和严重程度的环境因素。我们进行了系统回顾和定性分析，以全面了解产前和围产期因素与 TS 之间的关系。使用抽动秽语综合征特有的术语和“妊娠”、“产前”、“围产期”、“出生”和“新生儿”等关键词对 Medline、Embase 和 PsycINFO 数据库进行了搜索。研究仅限于 2012 年 10 月之前以英语或法语发表的人类受试者研究。其中包括 22 项研究。研究的方法学质量有限，大多数样本来自专科诊所，并且大多数暴露是回顾性确定的。大多数关于父母人口统计因素（包括年龄、教育程度、社会经济地位和婚姻状况）的结果显示，与 TS 的发病或合并症的存在没有显着关联。据报道，许多因素与 TS 的发病、合并症的存在和症状严重程度显着相关，但报告最一致的因素是母亲吸烟和低出生体重。很少有研究评估产前和围产期事件与 TS 之间的关系，并且现有研究存在重大局限性，包括使用临床样本而不是流行病学来源的样本、对产前和围产期事件的回顾性数据收集以及没有适当统计校正的多重假设检验。产前和围产期逆境导致 TS 发作或症状严重程度的机制尚不清楚，但可能与早期脑损伤导致的多巴胺能系统的变化有关。
Tourette Syndrome (TS) appears to be an inherited disorder, although genetic abnormalities have been identified in less than 1% of patients, and the mode of inheritance is uncertain. Many studies have investigated environmental factors that might contribute to the onset and severity of tics and associated comorbidities such as obsessive compulsive disorder (OCD) and attention deficit hyperactive disorder (ADHD). A systematic review and qualitative analysis were performed to provide a broad view of the association between pre- and perinatal factors and TS. The Medline, Embase and PsycINFO databases were searched using terms specific to Tourette’s syndrome and keywords such as “pregnancy”, “prenatal”, “perinatal”, “birth” and “neonatal”. Studies were limited to studies on human subjects published in English or French through October 2012. 22 studies were included. Studies were of limited methodological quality, with most samples derived from specialty clinics, and most exposures ascertained retrospectively. The majority of the results for demographic factors of parents, including age, education, socioeconomic status, and marital status, revealed no significant association with the onset of TS, or the presence of comorbidity. Many factors were reported to be significantly associated with the onset of TS, the presence of comorbidity and symptom severity, but the most consistently reported factors were maternal smoking and low birth weight. There are few studies evaluating the relationship between pre and perinatal events and TS, and existing studies have major limitations, including the use of clinic rather than epidemiologically derived samples, retrospective data collection on pre and perinatal events and multiple hypothesis testing without appropriate statistical correction. The mechanism by which prenatal and perinatal adversities could lead to TS onset or symptom severity is unknown, but may be related to changes in the dopaminergic system as a result of early brain injury.
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影响因子：
2.9
作者：
Klug, MG;Burd, L;Martsolf, JT
通讯作者：
Martsolf, JT
影响因子：
8.6
作者：
Bos-Veneman, Netty G. P.;Minderaa, Ruud B.;Hoekstra, Pieter J.
通讯作者：
Hoekstra, Pieter J.
影响因子：
11.9
作者：
Iida, J;Sakiyama, S;Ikawa, G
通讯作者：
Ikawa, G
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作者：
Eapen, V;Fox-Hiley, P;Robertson, M
通讯作者：
Robertson, M
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4.8
作者：
Bloch M;State M;Pittenger C
通讯作者：
Pittenger C