We like to move it, move it: A perspective on performing passive leg movement as a non-invasive assessment of vascular function in pediatric populations.
We like to move it, move it: A perspective on performing passive leg movement as a non-invasive assessment of vascular function in pediatric populations.
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DOI：
10.3389/fphys.2023.1165800
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
被动下肢运动（PLM）技术是一种无创评估下肢血管功能的方法。PLM在方法学上易于执行，并利用多普勒超声来确定静息时和小腿被动运动时通过股总动脉的腿部血流量（LBF）。据报道，在年轻人中进行PLM时，LBF反应主要是一氧化氮（NO）介导的。此外，PLM诱导的LBF反应，以及NO对PLM诱导的LBF反应的贡献，随着年龄的增长和在各种患病人群中减少，证明了这种非侵入性测试的临床实用性。然而，到目前为止，没有PLM研究包括儿童或青少年。自2015年成立以来，我们的实验室已经对数百名个体进行了PLM，其中包括一大批儿童和青少年。因此，这篇前瞻性文章的目的有三个：1）唯一讨论在儿童和青少年中进行PLM的可行性，2）报告我们实验室在7-17岁儿童中PLM诱导的LBF值，3）讨论在儿科人群中进行比较的考虑因素。根据我们在儿童和青少年（以及其他年龄组）中进行PLM的经验，我们认为PLM可以在这一人群中进行。此外，来自我们实验室的数据可用于提供典型PLM诱导的LBF值的背景，这些值可在儿童和青少年以及整个生命周期中观察到。
The passive leg movement (PLM) technique is a non-invasive assessment of lower-limb vascular function. PLM is methodologically simple to perform and utilizes Doppler ultrasound to determine leg blood flow (LBF) through the common femoral artery at rest and in response to passive movement of the lower leg. LBF responses to PLM have been reported to be mostly nitric oxide (NO)-mediated when performed in young adults. Moreover, PLM-induced LBF responses, as well as the NO contribution to PLM-induced LBF responses, are reduced with age and in various diseased populations, demonstrating the clinical utility of this non-invasive test. However, no PLM studies to date have included children or adolescents. Since its conception in 2015, our laboratory has performed PLM on hundreds of individuals including a large cohort of children and adolescents. Thus, the purpose of this perspective article is threefold: 1) to uniquely discuss the feasibility of performing PLM in children and adolescents, 2) to report PLM-induced LBF values from our laboratory in 7–17-year-olds, and 3) to discuss considerations for making comparisons among pediatric populations. Based on our experiences performing PLM in children and adolescents (among various other age groups), it is our perspective that PLM can feasibly be performed in this population. Further, data from our laboratory may be used to provide context for typical PLM-induced LBF values that could be observed in children and adolescents, as well as across the lifespan.
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影响因子：
3.5
作者：
Witman, Melissa A. H.;Ives, Stephen J.;Trinity, Joel D.;Groot, H. Jonathan;Stehlik, Josef;Richardson, Russell S.
通讯作者：
Richardson, Russell S.
影响因子：
--
作者：
Du Bois, D;Du Bois, EF
通讯作者：
Du Bois, EF
影响因子：
8.3
作者：
Harris, Ryan A.;Nishiyama, Steven K.;Richardson, Russell S.
通讯作者：
Richardson, Russell S.
DOI：
10.1152/ajpheart.00532.2012
发表时间：
2013-01-01
影响因子：
4.8
作者：
Ives, Stephen J.;McDaniel, John;Richardson, Russell S.
通讯作者：
Richardson, Russell S.
影响因子：
5.6
作者：
Hoopes, Elissa K.;Berube, Felicia R.;Witman, Melissa A. H.
通讯作者：
Witman, Melissa A. H.