CD8(+) T cells contribute to survival in patients with COVID-19 and hematologic cancer.
CD8(+) T cells contribute to survival in patients with COVID-19 and hematologic cancer.
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DOI：
10.1038/s41591-021-01386-7
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发表时间：
2021-07
期刊：
影响因子：
82.9
通讯作者：
Huang AC
中科院分区：
文献类型：
--
作者：
Bange EM;Han NA;Wileyto P;Kim JY;Gouma S;Robinson J;Greenplate AR;Hwee MA;Porterfield F;Owoyemi O;Naik K;Zheng C;Galantino M;Weisman AR;Ittner CAG;Kugler EM;Baxter AE;Oniyide O;Agyekum RS;Dunn TG;Jones TK;Giannini HM;Weirick ME;McAllister CM;Babady NE;Kumar A;Widman AJ;DeWolf S;Boutemine SR;Roberts C;Budzik KR;Tollett S;Wright C;Perloff T;Sun L;Mathew D;Giles JR;Oldridge DA;Wu JE;Alanio C;Adamski S;Garfall AL;Vella LA;Kerr SJ;Cohen JV;Oyer RA;Massa R;Maillard IP;Maxwell KN;Reilly JP;Maslak PG;Vonderheide RH;Wolchok JD;Hensley SE;Wherry EJ;Meyer NJ;DeMichele AM;Vardhana SA;Mamtani R;Huang AC
癌症患者死于新冠肺炎的死亡率很高，决定临床结果的免疫参数尚不清楚。在因新冠肺炎住院的100名癌症患者中，血液病患者的死亡率比实体癌患者更高。在另外两个队列中，流式细胞仪和血清学分析表明，实体癌和非癌症患者在急性新冠肺炎期间具有相似的免疫表型，而血液病患者B细胞受损和SARS-CoV-2特异性抗体反应。尽管新冠肺炎血液病患者体液免疫功能受损，死亡率高，但CD8T细胞数量较多的患者存活率有所提高，包括接受抗CD20T细胞治疗的患者。此外，77%的血液病患者有可检测到的SARS-CoV-2特异性T细胞反应。因此，当体液免疫缺陷时，CD8T细胞可能影响新冠肺炎的恢复。这些观察表明，即使在体液反应有限的情况下，CD8 T细胞对疫苗接种的反应也可能为血液病患者提供保护。
Cancer patients have high mortality from COVID-19, and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 cancer patients hospitalized for COVID-19, patients with hematologic cancers had higher mortality relative to solid cancers. In two additional cohorts, flow cytometric and serologic analyses demonstrated that solid cancer and non-cancer patients had a similar immune phenotype during acute COVID-19 whereas hematologic cancer patients had impairment of B cells and SARS-CoV-2-specific antibody responses. Despite the impaired humoral immunity and high mortality in hematologic cancer patients with COVID-19, those with a greater number of CD8 T cells had improved survival, including those treated with anti-CD20 therapy. Further, 77% of hematologic cancer patients had detectable SARS-CoV-2 specific T-cell responses. Thus, CD8 T cells may influence recovery from COVID-19 when humoral immunity is deficient. These observations suggest that CD8 T cell responses to vaccination might provide protection in hematologic cancer patients even in the setting of limited humoral responses.
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危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
24.8
作者：
Lee, Jeong Seok;Park, Seongwan;Shin, Eui-Cheol
通讯作者：
Shin, Eui-Cheol
影响因子：
24.8
作者：
Kuri-Cervantes, Leticia;Pampena, Maria Betina;Betts, Michael R.
通讯作者：
Betts, Michael R.
影响因子：
28.2
作者：
Dai, Mengyuan;Liu, Dianbo;Cai, Hongbing
通讯作者：
Cai, Hongbing