Regenerative pharmacology: recent developments and future perspectives.

Regenerative pharmacology: recent developments and future perspectives.
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再生药理学:最新发展和未来前景。

DOI:
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发表时间:
2016
影响因子:
2.7
通讯作者:
K. Andersson
K. Andersson
中科院分区:
工程技术4区
文献类型:
--
作者:
J. Williams;K. Andersson

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本综述重点关注利用药理学应用来加速、优化和表征生物工程和再生组织的发育、成熟和功能的研究现状。这些再生药理学方法已应用于泌尿生殖道、心脏、大脑、肌肉骨骼系统和糖尿病的疾病。方法包括使用生长因子(例如 VEGF 和趋化因子(基质衍生因子 - CXCL12))来动员细胞以应对组织损失或损伤。这种方法的前景是绕过细胞分离和植入物制造的漫长而昂贵的过程,以刺激身体通过自身的组织再生途径进行自我修复。
This review focuses on the current status of research that utilizes the application of pharmacological sciences to accelerate, optimize and characterize the development, maturation and function of bioengineered and regenerating tissues. These regenerative pharmacologic approaches have been applied to diseases of the urogenital tract, the heart, the brain, the musculoskeletal system and diabetes. Approaches have included the use of growth factors (such as VEGF and chemokines (stromal-derived factor - CXCL12) to mobilize cell to the sights of tissue loss or damage. The promise of this approach is to bypass the lengthy and expensive processes of cell isolation and implant fabrication to stimulate the body to heal itself with its own tissue regenerative pathways.
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