Effect of maternal restraint stress during gestation on temporal lipopolysaccharide-induced neuroendocrine and immune responses of progeny.
Effect of maternal restraint stress during gestation on temporal lipopolysaccharide-induced neuroendocrine and immune responses of progeny.
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DOI：
10.1016/j.domaniend.2010.08.005
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发表时间：
2011-01
影响因子：
2.1
通讯作者：
Laurenz, J. C.
中科院分区：
文献类型：
--
作者：
Collier, C. T.;Williams, P. N.;Carroll, J. A.;Welsh, T. H., Jr.;Laurenz, J. C.
评估了妊娠母鼠束缚应激对子代免疫和神经内分泌暂时激素对脂多糖（LPS）挑战的反应的影响。母体应激（妊娠第 84 至 112 天期间 5 分钟口部圈套器约束应激）增加 (P < 0.05) 子代输注 LPS 后肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-6、肾上腺素 (E)、去甲肾上腺素 (NE) 和血清淀粉样蛋白 A (SAA) 的产生量。此外，这些影响似乎取决于 TNF-α、E、EPI 和皮质醇产生的性别。然而，母体压力并不影响（P > 0.05）LPS 后产生的促炎细胞因子或神经内分泌激素的正常化。总的来说，这些结果表明，在给后代服用 LPS 后，母体应激会影响其后代的促炎细胞因子和应激激素反应。这种反应可能是 SAA 生产发生变化的部分原因。由于这里观察到的一些变化取决于猪的性别，这些结果也是第一个证据，表明固有的表观遗传因素与母体应激相结合会影响幼猪对应激和 LPS 的累积反应。
The impact of gestational dam restraint stress on progeny immune and neuroendocrine temporal hormone responses to lipopolysaccharide (LPS) challenge was assessed. Maternal stress (5-min snout snare restraint stress during d 84 to 112 of gestation) increased (P < 0.05) the magnitude of tumor necrosis factor (TNF)-α, interleukin (IL)-6, epinephrine (E), norepinephrine (NE) and serum amyloid A (SAA) production following LPS infusion in the offspring. Moreover, these effects appear to be dependent on gender for TNF-α, E, EPI and cortisol production. However, maternal stress did not affect (P > 0.05) the normalization of proinflammatory cytokines or neuroendocrine hormones produced following LPS. Collectively, these results indicate that maternal stress impacts aspects of the proinflammatory cytokine and stress hormone response in their progeny following LPS dosing of the offspring. This response is potentially responsible in part for the resultant changes to SAA production. As several of the changes observed here are dependent on pig gender, these results are also the first evidence that inherent epigenetic factors coupled with maternal stress impacts the cumulative response to stress and LPS in young pigs.
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影响因子：
9.1
作者：
Suffredini, AF;Fantuzzi, G;O'Grady, NP
通讯作者：
O'Grady, NP
影响因子：
2
作者：
Trout, JM;Mashaly, MM;Siegel, HS
通讯作者：
Siegel, HS
影响因子：
14.2
作者：
von Hertzen, LC
通讯作者：
von Hertzen, LC
影响因子：
3.3
作者：
Burdick, N. C.;Banta, J. P.;Randel, R. D.
通讯作者：
Randel, R. D.
影响因子：
2.9
作者：
de Groot, Johanna;Kranendonk, Godelieve;Taverne, Marcel
通讯作者：
Taverne, Marcel