Elevated Plasma Levels of Soluble (Pro)Renin Receptor in Patients with Obstructive Sleep Apnea Syndrome in Parallel with the Disease Severity.
Elevated Plasma Levels of Soluble (Pro)Renin Receptor in Patients with Obstructive Sleep Apnea Syndrome in Parallel with the Disease Severity.
复制标题
阻塞性睡眠呼吸暂停综合征患者的可溶性（原）肾素受体血浆水平与疾病严重程度同时升高。
DOI：
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发表时间：
2016
影响因子：
2.2
通讯作者：
S. Sakurai
中科院分区：
文献类型：
--
作者：
Tsuguo Nishijima;Kazuki Tajima;Y. Yamashiro;K. Hosokawa;A. Suwabe;Kazuhiro Takahashi;S. Sakurai
（Pro）renin receptor（（P）RR）是肾素和原肾素的受体，参与糖尿病、高血压及其并发症的病理生理过程。可溶性（P）RR（s（P）RR）由（P）RR的胞外结构域组成，因此存在于血液中。我们报道了阻塞性睡眠呼吸暂停综合征（OSAS）男性患者血浆s（P）RR浓度升高。本研究的目的是阐明男性和女性OSAS患者血浆s（P）RR浓度的差异。对259例OSAS患者和30例非OSAS对照者289例（男206例，女83例）血浆s（P）RR浓度进行了研究。将259例OSAS患者分为轻度（5例≤呼吸暂停低通气指数（AHI）< 15次/h）、中度（15例≤ AHI < 30）和重度（AHI ≥ 30）。与非OSAS对照组（AHI < 5）和男性受试者相比，所有三组OSAS患者血浆s（P）RR水平均显著升高，而在女性受试者中，仅在重度OSAS患者中发现显著升高。血浆s（P）RR水平与AHI呈显著正相关，男性r值较高（男性r = 0.413，p < 0.0001;女性r = 0.263，p < 0.05）。重要的是，当AHI ≥ 20的OSAS患者（26名男性和15名女性）接受持续气道正压通气治疗时，血浆s（P）RR水平显著降低。结论：男性和女性OSAS患者血浆s（P）RR水平升高与疾病严重程度平行。
(Pro)renin receptor ((P)RR), a receptor for renin and prorenin, is implicated in the pathophysiology of diabetes mellitus, hypertension and their complications. Soluble (P)RR (s(P)RR) is composed of extracellular domain of (P)RR and thus exists in blood. We have reported that plasma concentrations of s(P)RR were elevated in male patients with obstructive sleep apnea syndrome (OSAS). The aim of the present study was to clarify the difference in plasma s(P)RR concentrations between male and female OSAS patients. Plasma s(P)RR concentrations were studied in 289 subjects (206 males and 83 females) consisting of 259 OSAS patients and 30 non-OSAS control subjects. The 259 OSAS patients were classified into mild (5 ≤ apnea hypopnea index (AHI) < 15 events/h), moderate (15 ≤ AHI < 30), and severe OSAS (AHI ≥ 30). Plasma s(P)RR levels were significantly elevated in all three OSAS groups compared to non-OSAS control subjects (AHI < 5) in the entire cohort and male subjects, whereas in female subjects, the significant elevation was found only in severe OSAS. Plasma s(P)RR levels were significantly correlated with AHI in both sexes, with a higher r value found in male subjects (male r = 0.413, p < 0.0001; female r = 0.263, p < 0.05). Importantly, when OSAS patients (26 males and 15 females) with AHI ≥ 20 underwent continuous positive airway pressure treatment, plasma s(P)RR levels were significantly decreased. In conclusion, plasma s(P)RR levels are elevated in both male and female OSAS patients in parallel with the disease severity.
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影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
影响因子：
13.6
作者：
Ichihara, Atsuhiro;Suzuki, Fumiaki;Inagami, Tadashi
通讯作者：
Inagami, Tadashi
影响因子：
37.8
作者：
Narkiewicz, K;Kato, M;Somers, VK
通讯作者：
Somers, VK
影响因子：
19.6
作者：
Huang, Y;Wongamorntham, S;Border, W
通讯作者：
Border, W