The pathogenesis, detection, and prevention of Vibrio parahaemolyticus.
The pathogenesis, detection, and prevention of Vibrio parahaemolyticus.
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DOI：
10.3389/fmicb.2015.00144
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发表时间：
2015
影响因子：
5.2
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Wang R;Zhong Y;Gu X;Yuan J;Saeed AF;Wang S
副溶血弧菌是一种革兰氏阴性运动细菌，栖息在世界各地的海洋和河口环境中，是一种主要的食源性病原体，在人类食用生的或未煮熟的海鲜后会导致危及生命的疾病。副溶血性弧菌在全球的出现凸显了研究其毒力因子及其对人类宿主影响的重要性。本综述介绍了迄今为止报道的副溶血性弧菌的毒力因子，包括溶血素、脲酶、两种III型分泌系统和两种VI型分泌系统，它们都会引起培养细胞的细胞毒性和动物模型的肠毒性。我们描述了基于毒力因子的各种类型的检测方法，用于定量检测海鲜中的副溶血弧菌。我们还讨论了一些针对副溶血弧菌介导的疾病的有用的预防措施和治疗策略，可以在一定程度上减少副溶血弧菌对人类和水生动物的危害。这篇综述扩展了我们对毒力因子介导的副溶血弧菌致病机制及其在人类宿主中引起的疾病的理解。它应该为副溶血性弧菌感染的诊断、治疗和预防提供新的见解。
Vibrio parahaemolyticus, a Gram-negative motile bacterium that inhabits marine and estuarine environments throughout the world, is a major food-borne pathogen that causes life-threatening diseases in humans after the consumption of raw or undercooked seafood. The global occurrence of V. parahaemolyticus accentuates the importance of investigating its virulence factors and their effects on the human host. This review describes the virulence factors of V. parahaemolyticus reported to date, including hemolysin, urease, two type III secretion systems and two type VI secretion systems, which both cause both cytotoxicity in cultured cells and enterotoxicity in animal models. We describe various types of detection methods, based on virulence factors, that are used for quantitative detection of V. parahaemolyticus in seafood. We also discuss some useful preventive measures and therapeutic strategies for the diseases mediated by V. parahaemolyticus, which can reduce, to some extent, the damage to humans and aquatic animals attributable to V. parahaemolyticus. This review extends our understanding of the pathogenic mechanisms of V. parahaemolyticus mediated by virulence factors and the diseases it causes in its human host. It should provide new insights for the diagnosis, treatment, and prevention of V. parahaemolyticus infection.
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