Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes.
Nanoprobes-Assisted Multichannel NIR-II Fluorescence Imaging-Guided Resection and Photothermal Ablation of Lymph Nodes.
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纳米探针辅助多通道 NIR-II 荧光成像引导淋巴结切除和光热消融
DOI：
10.1002/advs.202003972
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Lin H
中科院分区：
文献类型：
--
作者：
Fan X;Li Y;Feng Z;Chen G;Zhou J;He M;Wu L;Li S;Qian J;Lin H
淋巴结转移是癌症的主要转移途径，对癌症患者的预后有重要影响。根治性淋巴清扫是手术成功的关键。然而，在淋巴清扫术中，医源性正常器官损伤是一个麻烦的并发症。本文报道了一种具有优良的二次近红外(NIR-II)荧光和光热性能的有机纳米探针(IDSE-IC2F纳米粒子)。IDSE-IC2F纳米粒子可以有效地标记淋巴结，并帮助实现高对比度淋巴成像。更重要的是，通过联合使用IDSE-IC2F纳米粒子和其他不同激发/发射性质的纳米粒子，提出了一种多通道NIR-II荧光成像方式和成像引导下的淋巴清扫。在这种导航系统的帮助下，医源性损伤可以在很大程度上避免。此外，NIR-II荧光成像引导的光热治疗(“热”策略)可以消融那些在切除过程中难以处理的转移性淋巴结(“冷”策略)。纳米探针辅助和多通道NIR-II荧光成像引导的冷热治疗策略为未来的精密手术提供了普遍的新依据。合成了一种新型的二次近红外(NIR-II)荧光纳米探针用于标记和示踪淋巴结。与其他类型的具有不同光学特性的NIR-II荧光纳米颗粒一起，成功地进行了多通道荧光成像引导手术。转移性淋巴结的光热消融是手术的一个很好的补充。这个平台提供了一个新的视角，通过它可以进行更精确的手术。
Lymph node metastasis is a major metastatic route of cancer and significantly influences the prognosis of cancer patients. Radical lymphadenectomy is crucial for a successful surgery. However, iatrogenic normal organ injury during lymphadenectomy is a troublesome complication. Here, this paper reports a kind of organic nanoprobes (IDSe‐IC2F nanoparticles (NPs)) with excellent second near‐infrared (NIR‐II) fluorescence and photothermal properties. IDSe‐IC2F NPs can effectively label lymph nodes and helped achieve high‐contrast lymphatic imaging. More importantly, by jointly using IDSe‐IC2F nanoparticles and other kinds of nanoparticles with different excitation/emission properties, a multichannel NIR‐II fluorescence imaging modality and imaging‐guided lymphadenectomy is proposed. With the help of this navigation system, the iatrogenic injury can be largely avoided. In addition, NIR‐II fluorescence imaging‐guided photothermal treatment (“hot” strategy) can ablate those metastatic lymph nodes which are difficult to deal with during resection (“cold” strategy). Nanoprobes‐assisted and multichannel NIR‐II fluorescence imaging‐guided “cold” and “hot” treatment strategy provides a general new basis for the future precision surgery. A novel kind of second near‐infrared (NIR‐II) fluorescent nanoprobe is synthesized to label and trace lymph nodes (LNs). Together with other kinds of NIR‐II fluorescent NPs with different optical features, multichannel fluorescence imaging‐guided surgeries are successfully conducted. Photothermal ablation of metastatic LNs is introduced as a good complement to surgery. This platform offers a novel perspective through which a more precise surgery can be conducted.
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影响因子：
16.6
作者：
Wang P;Fan Y;Lu L;Liu L;Fan L;Zhao M;Xie Y;Xu C;Zhang F
通讯作者：
Zhang F
影响因子：
16.6
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作者：
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29
作者：
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通讯作者：
Mazzone, Massimiliano
一种新型多模态 NIR-II 纳米探针，用于检测口腔鳞状细胞癌的转移性淋巴结和靶向化学光热治疗
影响因子：
12.4
作者：
Wang, Yufeng;Zhang, Wansu;Han, Wei
通讯作者：
Han, Wei