Locomotor activity modulates associative learning in mouse cerebellum.
Locomotor activity modulates associative learning in mouse cerebellum.
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DOI：
10.1038/s41593-018-0129-x
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发表时间：
2018-05
影响因子：
25
通讯作者：
Carey MR
中科院分区：
文献类型：
--
作者：
Albergaria C;Silva NT;Pritchett DL;Carey MR
行为状态的改变会对大脑功能产生深远影响。在这里，我们展示了行为状态调节延迟眨眼条件反射的表现，这是一种依赖小脑的联想学习形式。头部固定小鼠运动速度的增加导致学习开始得更早，学习反应的逐步增强与觉醒的变化无关，不受感觉通道的影响。由小脑苔藓纤维输入的光遗传刺激引起的眼皮反应，而不是下游部位，被持续的运动正向调制。用长时间、低强度的光遗传苔藓纤维刺激代替运动足以增强条件性反应。我们的结果表明，运动活动通过增加小脑内苔藓纤维通路的激活来调节延迟眨眼条件反射。综上所述，这些结果为行为状态调节在联想学习中扮演的新角色提供了证据，并提出了一种潜在的机制，通过参与运动可以提高个人的学习能力。
Changes in behavioral state can profoundly influence brain function. Here we show that behavioral state modulates performance in delay eyeblink conditioning, a cerebellum-dependent form of associative learning. Increased locomotor speed in head-fixed mice drove earlier onset of learning and trial-by-trial enhancement of learned responses that were dissociable from changes in arousal and independent of sensory modality. Eyelid responses evoked by optogenetic stimulation of mossy fiber inputs to the cerebellum, but not at sites downstream, were positively modulated by ongoing locomotion. Substituting prolonged, low-intensity optogenetic mossy fiber stimulation for locomotion was sufficient to enhance conditioned responses. Our results suggest that locomotor activity modulates delay eyeblink conditioning through increased activation of the mossy fiber pathway within the cerebellum. Taken together, these results provide evidence for a novel role for behavioral state modulation in associative learning and suggest a potential mechanism through which engaging in movement can improve an individual’s ability to learn.
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影响因子：
16.2
作者：
Bennett C;Arroyo S;Hestrin S
通讯作者：
Hestrin S
影响因子：
5.3
作者：
Heiney, Shane A.;Kim, Jinsook;Medina, Javier F.
通讯作者：
Medina, Javier F.
DOI：
10.1073/pnas.0808428106
发表时间：
2009-02-17
影响因子：
11.1
作者：
Bengtsson, Fredrik;Jorntell, Henrik
通讯作者：
Jorntell, Henrik
影响因子：
16.2
作者：
Arenkiel, Benjamin R.;Peca, Joao;Feng, Guoping
通讯作者：
Feng, Guoping
影响因子：
16.2
作者：
Gao Z;Proietti-Onori M;Lin Z;Ten Brinke MM;Boele HJ;Potters JW;Ruigrok TJ;Hoebeek FE;De Zeeuw CI
通讯作者：
De Zeeuw CI