INTERLEUKIN-1β STIMULATES SOMATOSTATIN BIOSYNTHESIS IN PRIMARY CULTURES OF FETAL RAT BRAIN
INTERLEUKIN-1β STIMULATES SOMATOSTATIN BIOSYNTHESIS IN PRIMARY CULTURES OF FETAL RAT BRAIN
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INTERLEUKIN-1β 刺激胎鼠大脑原代培养物中生长抑素的生物合成
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
S. Reichlin
中科院分区：
文献类型：
--
作者：
D. Scarborough;STEPHANIE L. Lee;C. Dinarello;S. Reichlin
Interleukin-1 (IL-1), a secretory product of activated macrophages and many other cell types, is an important mediator of the acute phase reaction to infection and to endotoxin administration. Previous reports that GH and TSH secretion are decreased following injection of endotoxin or IL-1 led us to test the hypothesis that IL-1 acts by releasing increased amounts of somatostatin (SS), a hypothalamic factor inhibitory of both GH and TSH release. Primary cultures of dispersed fetal rat diencephalic cells were found to contain increasing amounts of immunoreactive SS in both cells and media after addition of recombinant human IL-1β. This increase was detectable at 24 hours and continued for up to 6 days, the longest time interval tested. Increased content of SS peptide was accompanied by marked increases in SS mRNA. These changes were dose-related, the lowest effective dose being 10−10M. In contrast to the long term response, exposure of the cells to IL-1β for one hour had only minimal stimulating effects on...
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未麻醉大鼠中位隆起的生长抑素释放：与药物抑制生长激素分泌缺乏相关性。
影响因子：
4.1
作者：
Fukata,J;Kasting,NW;Martin,JB
通讯作者：
Martin,JB
影响因子：
3.9
作者：
Pal, Nabanita;Kim, Taeyeon;Park, Jae-Seo;Cho, Eun-Bum
通讯作者：
Cho, Eun-Bum
重组白介素 1 和肿瘤坏死因子对人星形细胞瘤细胞系的生长促进作用。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lachman,LB;Brown,DC;Dinarello,CA
通讯作者：
Dinarello,CA
影响因子：
56.9
作者：
SAPOLSKY, R;RIVIER, C;VALE, W
通讯作者：
VALE, W
影响因子：
56.9
作者：
BREDER, CD;DINARELLO, CA;SAPER, CB
通讯作者：
SAPER, CB